Single dose oral meloxicam for acute postoperative pain in adults

Moore, R Andrew; Derry, Sheena; McQuay, Henry J

doi:10.1002/14651858.cd007552

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…As a result, updated NNTs are available for some analgesics used for postoperative pain. Additional data for ibuprofen [24], diclofenac [25] and naproxen [26] confirmed NNTs in the range of 2-3.5, suggesting effective analgesia; the lack of evidence for some other nonsteroidal anti-inflammatory drug (NSAID) preparations suggests alternatives should be used [27][28][29].…”

Section: League Tables Of Analgesic Efficacymentioning

confidence: 97%

The scientific evidence for acute pain treatment

Macintyre

Walker

2010

Current Opinion in Anaesthesiology

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Section: League Tables Of Analgesic Efficacymentioning

confidence: 97%

The scientific evidence for acute pain treatment

Macintyre

Walker

2010

Current Opinion in Anaesthesiology

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“…A Cochrane review recently attempted to evaluate the efficacy of oral meloxicam in acute post-operative pain, summarizing results from randomized double-blind placebo-controlled clinical trials involving meloxicam for acute post-operative pain relief. [27] Unfortunately, none of the studies examined met inclusion criteria for analysis.…”

Section: Perioperative Use Of Meloxicammentioning

confidence: 99%

Meloxicam in the management of post-operative pain: Narrative review

Bekker

Kloepping

Collingwood

2018

J Anaesthesiol Clin Pharmacol

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Oral formulations of meloxicam, a preferential cyclooxygenase-2 (COX-2) inhibitor, have long been used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, as well as various pain syndromes of skeletomuscular origin (e.g., low back pain). However, these preparations are rarely indicated for the treatment of acute pain due to a poor dissolution rate and consequently a slow onset of action. The recent introduction of an intravenous (IV) NanoCrystal Colloidal Dispersion formulation opens up the possibility of using this drug during the perioperative period. The present review summarizes the pharmacologic properties of meloxicam, including its pharmacokinetics, adverse effects, and tolerability. In addition, we critically examined a number of recently completed clinical trials that evaluated the efficacy and safety of meloxicam IV in the treatment of post-operative pain. Literature retrieval was performed through PubMed and Medline (through March 2018) using combinations of the terms meloxicam, acute pain, and pharmacology. In addition, bibliographical information, including contributory unpublished data, was requested from the company developing the drug. Clinical trials suggest that single IV doses of 30 mg meloxicam significantly reduce post-operative pain as well as opioid requirements. We conclude that meloxicam IV is an effective and well-tolerated analgesic agent for the management of moderate to severe post-operative pain.

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“…In recent years, some clinical trials have been carried out on the analgesic effect of meloxicam following orofacial surgery. A review article in the year 2009 on placebo‐controlled randomized controlled trial studies evaluated the analgesic effect of meloxicam after surgical procedures, but did not report any study in this regard, which seems to be due to reasons such as the limited choice of searched databases, evaluation of studies that had placebo and publication of the related studies in recent years.…”

Section: Introductionmentioning

confidence: 99%

Post‐operative pain management with meloxicam: a systematic literature review in the field of dentistry

et al. 2019

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Aim: Pain is one of the clinical problems after orofacial surgeries. There have been various studies about the analgesic effect of nonsteroidal antiinflammatory drugs (NSAIDs) in this group of surgeries. In recent years, meloxicam has undergone clinical trials in dentistry. The purpose of this study was to review the efficacy of meloxicam on postoperative pain in dentistry. Materials and methods: The study design was in accordance with the PRISMA guidance. The keywords according to MeSH and related articles were searched in the EBSCO, MEDLINE (via Ovid), PubMed, Science Direct, Scopus, Web of Science and Google Scholar databases. Then eligible randomized clinical trials articles, which released up to December 2017, were thoroughly reviewed. Results: The nine eligible articles were studied. Meloxicam was administered with doses of 7.5, 10 and 15 mg (oral or intramuscular) before or after the third molar extraction. Meloxicam has a similar or significantly better analgesic effect than some of the selective and nonselective NSAIDs and significantly has a better analgesic effect than some of salicylic acids and tramadol. Conclusion: Meloxicam can be considered as an alternative analgesic agent than some NSAIDs, tramadol and salicylic acids in patients who have undergone the third molar extraction.The best way to pain intensity control following orofacial surgeries has not yet been introduced. According to a common rule, non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen or their combination are the most prescribed items for of pain intensity control after orofacial surgery 6,7 .Up to now, many studies have been conducted to evaluate the effectiveness of different analgesic drugs, including opioids, corticosteroids, salicylic acids and NSAIDs in dentistry. Generally, selective cyclooxygenase-2 (COX-2) inhibitor NSAIDs may be preferred over their non-selective ones in terms of pain intensity control and a decrease in additional Oral Surgery 13 (2020) 188--196.

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Single dose oral meloxicam for acute postoperative pain in adults

Abstract: Morris 1995 Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratio and standardised ratios and rates.

Cited by 3 publications

References 30 publications

The scientific evidence for acute pain treatment

The scientific evidence for acute pain treatment

Meloxicam in the management of post-operative pain: Narrative review

Post‐operative pain management with meloxicam: a systematic literature review in the field of dentistry

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