Single Embryo Transfer in IVF to Prevent Multiple Pregnancies

Catt, James; Wood, Tina; Henman, Michael; Jansen, Robert P.S.

doi:10.1375/twin.6.6.536

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…The aim is to benefit both from the higher chance of conception that comes from the additional blastocyst that was stored instead of transferred fresh, as well as from the reduced risk of twin‐based perinatal loss 2 . We are able to show that when there are two or more blastocysts available for transfer, the cumulative chance of delivering a baby that survives the neonatal period (whether from a fresh or from a frozen blastocyst) is now 64% if two blastocysts were transferred fresh, but 65% if only one blastocyst was transferred fresh 23,24 ; the twinning rates have been 34% and 7%, respectively (the latter mainly from subsequent twin transfers of thawed blastocysts).…”

Section: Miscarriage Prematurity and Multiple Pregnanciesmentioning

confidence: 80%

Benefits and challenges brought by improved results from in vitro fertilization

Jansen

2005

Internal Medicine Journal

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In vitro fertilization (IVF), in which preimplantationstage embryos are produced after ovarian stimulation and retrieval of preovulatory oocytes, now accounts for almost 2% of all births in Australia. For clinics performing in the top quartile of national results, the chance of a live birth for a woman under 35 years from one round of egg retrieval and IVF treatment is greater than 50%, albeit still with a greater than 20% risk of twins or higher order multiple pregnancy. Similar or better live birth rates are now obtainable with the elective transfer of a single embryo at the stage of blastocyst (5-6 days in culture), a policy that if adopted for younger women can reduce the risk of twins in a clinic to less than 15%. Current developments centre around improvements to embryo culture and the testing of embryos for chromosomal normality and other genetic and epigenetic variables before transfer, made possible by licences for embryo research protocols now being issued under the

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Section: Miscarriage Prematurity and Multiple Pregnanciesmentioning

confidence: 80%

Benefits and challenges brought by improved results from in vitro fertilization

Jansen

2005

Internal Medicine Journal

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“…In Australia, the accreditation system operated by the Fertility Society of Australia (Reproductive Technology Accreditation Committee, RTAC) requests clinics generally transfer no more than two embryos in one treatment cycle. Many clinicians would transfer two embryos per cycle, although SET has been proposed as the better clinical option 4 . Despite increased attention to the risk of multiple births in patient information and counselling practice, many Australian IVF clinics and a large proportion of patients continue to choose double embryo transfer.…”

Section: Boxmentioning

confidence: 99%

Reducing multiple pregnancy from assisted reproduction treatment: educating patients and medical staff

Wang

Lane

Norman

2006

Medical Journal of Australia

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Multiple pregnancy, with its adverse outcomes, is a significant problem in assisted reproductive technology. Single embryo transfer (SET) is the only feasible solution for reducing the rate of multiple pregnancy. Many patients and some clinicians remain to be convinced that SET is a better clinical option. Adequate education, based on available evidence, is one important way to promote the use of SET.

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“…In 2000 we therefore introduced elective single blastocyst transfer (eSBT) for younger women with a good prognosis for IVF pregnancy. Women who elected to have SBT actually had a slightly higher chance of taking home a healthy baby, as neonatal morbidity from premature multiple pregnancy declined 2–4 …”

Section: The Effect Of Blastocyst Practices On Multiple Pregnancymentioning

confidence: 99%