Single embryo transfer: Why and how to identify the embryo with the best developmental potential

Tiitinen, Aila

doi:10.1016/j.beem.2019.04.001

Cited by 25 publications

(18 citation statements)

References 58 publications

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“…Embryo quality is primarily assessed through an embryo grading system where embryos are graded according to their morphological appearance and are given a score that relates to their development at the time of assessment [10]. The goal is to provide a more precise estimate of implantation potential [11].…”

Section: Introductionmentioning

confidence: 99%

Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF

Tomić

Kasum

Vučić

2020

Arch Gynecol Obstet

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The aim of this study is to assess the effect of the endometrial thickness and embryo quality on the implantation potential in natural cycle IVF (NC-IVF). Methods A retrospective single-center study was performed on 552 single embryo transfers after NC-IVF. The 'quality' of the embryos was evaluated trough the number and regularity of blastomeres, degree of fragmentation, and nuclear content of cells. Endometrial thickness was measured in millimeters with transvaginal ultrasound on the day of hCG application. Results Our findings showed a statistically significant difference in successful implantation until a plateau of 10 mm is reached (p = 0.001). Only one pregnancy was achieved where endometrial thickness was less than 7 mm, and this resulted in an early miscarriage. The predictors of favorable implantation were fragmentation (≤ 10%, p < 0.05) and the number of blastomeres (preferably 8-cell, p < 0.01) on day 3. Embryo quality (R = 0.052) and endometrial thickness (R = 0.18) were closely related to pregnancy rate. The overall implantation rate per embryo transfer was 18.8%. Conclusions Embryo quality and endometrial thickness have a significant impact on implantation in NC-IVF. Highest implantation potential has an 8-cell embryo with ≤ 10% fragmentation in the third day following oocyte retrieval. Endometrial thickness of at least 7 mm seems to be the optimal edge of successful pregnancy.

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Section: Introductionmentioning

confidence: 99%

Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF

Tomić

Kasum

Vučić

2020

Arch Gynecol Obstet

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“…Multiple pregnancies pose a potential health risk for the mother, including pregnancy-induced hypertension and postpartum haemorrhage [9]. Hence, several countries (such as Finland, Sweden, Belgium, Australia and New Zealand) have employed elective single embryo transfer to reduce the possibility of multiple gestation and eventual complications [10,11]. However, many countries are yet to adopt the strict regulations in ART practice, presumably due to the expense involved coupled with the patient's hope to achieve pregnancy in each cycle with better chances.…”

Section: Introductionmentioning

confidence: 99%

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

et al. 2020

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Infertility affects approximately 15–20% of individuals of reproductive age worldwide. Over the last 40 years, assisted reproductive technology (ART) has helped millions of childless couples. However, ART is limited by a low success rate and risk of multiple gestations. Devising methods for selecting the best gamete or embryo that increases the ART success rate and prevention of multiple gestation has become one of the key goals in ART today. Special emphasis has been placed on the development of non-invasive approaches, which do not require perturbing the embryonic cells, as the current morphology-based embryo selection approach has shortcomings in predicting the implantation potential of embryos. An observed association between embryo metabolism and viability has prompted researchers to develop metabolomics-based biomarkers. Nuclear magnetic resonance (NMR) spectroscopy provides a non-invasive approach for the metabolic profiling of tissues, gametes and embryos, with the key advantage of having a minimal sample preparation procedure. Using NMR spectroscopy, biologically important molecules can be identified and quantified in intact cells, extracts or secretomes. This, in turn, helps to map out the active metabolic pathways in a system. The present review covers the contribution of NMR spectroscopy in assisted reproduction at various stages of the process.

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“…Although implantation is a complex process that depends on a coordinated cross-talk between the endometrial factors and the embryo itself, a proper embryo quality is one of the factors that play an important role in embryo implantation [48]. Moreover, the bioactivity of platelets is one of the several factors (genomic, transcriptomic, proteomic, metabolomic, The Cause of infertility male factor 28% 32% cytokines, growth factors, hormones, and the embryo itself) that are involved in the mechanism of endometrial receptivity [49].…”

Section: Discussionmentioning

confidence: 99%

The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

Allahveisi

Seyedoshohadaei

Rezaei

et al. 2020

Heliyon

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The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on the rate of implantation and pregnancy in women with repeated failed implantation during frozen embryo transfer. Methods: This study was conducted on 50 infertile women candidates (who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj) with a history of failed implantation for the purpose of frozen embryo transfer. The participants were randomly divided into two groups (n ¼ 25). In the first group (control), the intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer. In the second group (treatment), the intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer. Results: In this study, there was no significant difference between the two groups in the rate of chemical and clinical pregnancy. The rate of chemical pregnancy was 28% in the treatment group and 36% in the control group, while the rate of clinical pregnancy was 28% in the treatment group and 24% in the control group. Conclusion:The intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of failed implantation will not make any significant effect on the result of pregnancy.

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Single embryo transfer: Why and how to identify the embryo with the best developmental potential

Cited by 25 publications

References 58 publications

Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF

Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

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