The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

Allahveisi, Azra; Seyedoshohadaei, Fariba; Rezaei, Mohammad Jafar; Bazrafshan, Narges; Rahimi, Kaveh

doi:10.1016/j.heliyon.2020.e03577

Cited by 24 publications

(33 citation statements)

References 44 publications

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“…However, contradictory views on the usefulness of PRP perfusion treatment in IVF reproductive medicine persists. Tehraninejad and Allahveisi found that the pregnancy outcomes, namely, the clinical and ongoing pregnancy rates, live birth rates were similar between the PRP intrauterine infusion group and the control group in RIF patients of FET cycles ( 10 , 11 ). The reason for the inconsistency between our results and those of others might be attributable to the different subject cohorts, different definitions of RIF and wide variety of PRP preparation protocols.…”

Section: Discussionmentioning

confidence: 90%

“…To date, only a few RCT studies on intrauterine infusion of PRP have been performed in the reproductive field. Eftekhar and Nazari suggested that PRP could expand the thin endometrium and improve clinical pregnancy outcomes ( 17 , 20 ), while Allahveisi's study concluded that intrauterine infusion of PRP did not improve pregnancy outcomes in patients with recurrent implantation failure ( 11 ). Design of placebo in the control group was inconsistent across studies.…”

Section: Discussionmentioning

confidence: 99%

“…Studies in recent years have shown great promise in reproduction fields. Many studies have demonstrated that autologous PRP can regenerate and thicken the thin endometrium and decrease the likelihood of implantation failure leading to good pregnancy outcomes ( 9 – 11 ), however the patient's heterogeneity and small sample size of the subjects led to different research results, therefore this research analyzed the use of PRP before embryo transfer in RIF patients of frozen thawed cycles and its efficacy in this population.…”

Section: Introductionmentioning

confidence: 99%

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Intrauterine Perfusion of Autologous Platelet-Rich Plasma Before Frozen-Thawed Embryo Transfer Improves the Clinical Pregnancy Rate of Women With Recurrent Implantation Failure

Hao

Fang

et al. 2022

Front. Med.

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ObjectiveTo evaluate whether the intrauterine perfusion of platelet-rich plasma (PRP) before frozen-thawed embryo transfer (FET) improves the pregnancy outcomes of patients with repeated implantation failure (RIF).MethodsThis retrospective study included 288 infertile women with RIF after undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from October 1, 2019, to January 1, 2021, at Qingdao Women and Children's Hospital. Patients were divided into two groups according to whether they received PRP intrauterine perfusion before embryo transfer in FET cycles. 138 women were in the PRP group, 150 women were in the control group. The primary outcome measure was live birth rates and the secondary outcome were clinical pregnancy, positive β hCG, miscarriage and implantation rates.ResultsNo significant differences in baseline demographic and clinical characteristics were observed between the two groups. Overall, significantly more women in the PRP group than in the control group achieved a live birth rate (41 women; 29.71% vs. 27 women; 18%) and a clinical pregnancy (50 women; 36.23% vs. 37 women; 24.67%). The PRP group had a higher implantation rate and lower spontaneous miscarriage rate than the control group, but these differences were not statistically significant. No pregnancy outcome difference between two groups in PCOS patients with RIF.ConclusionOur results showed that intrauterine perfusion of PRP before embryo transfer in FET cycles can significantly increase the live birth and clinical pregnancy rates in patients with RIF.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intrauterine Perfusion of Autologous Platelet-Rich Plasma Before Frozen-Thawed Embryo Transfer Improves the Clinical Pregnancy Rate of Women With Recurrent Implantation Failure

Hao

Fang

et al. 2022

Front. Med.

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“…In infertile women with a history of failed implantation, intrauterine PRP infusion before frozen ET was found to have no significant effect on pregnancy [16]. A prospective cohort with a large number of patients is necessary to explore the underlying mechanisms responsible for PRP's beneficial effects and further investigate the benefits of PRP treatment in women with a thin endometrium who have undergone frozen ET (FET).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Autologous Platelet-Rich Plasma Treatment on In Vitro Fertilization/Intracytoplasmic Sperm Injection and Its Impact on the Endometrium and Clinical Pregnancy Rate

Abduljabbar¹,

Hashim²,

Abduljabar³

et al. 2022

Cureus

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BackgroundEndometrial thickness has been identified as a prognostic factor for improving the pregnancy rate for patients with female infertility. Study questionDoes platelet-rich plasma (PRP) treatment affect the endometrial thickness and pregnancy rate after an in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle? AimThis study aims to evaluate the effects of autologous PRP treatment on IVF/ICSI, endometrium, and clinical pregnancy rate. Materials, setting, and methodsThis is a prospective, non-blind, randomized controlled study. The ethical committee of the Jeddah IVF Center approved the study, and informed written consent was obtained from all patients. We recruited patients who consulted at the Jeddah IVF Center from September 2020 to May 2021. ResultsA total of 70 patients undergoing IVF/ICSI and embryo transfer (ET) were randomly divided by simple randomization into two groups: those who received PRP treatment after oocyte pickup (OPU) (group A) and those who did not receive PRP treatment (control, group B). The endometrial thickness was measured after OPU and before ET. The mean ages of patients in groups A and B were 35.91 ± 4.09 (range: 24-43) and 34.63 ± 4.26 (range: 25-43), respectively, which were not statistically significant (P < 0.223). In the PRP cases, the types of infertility were primary in 16 (45.7%) and secondary in 19 (54.3%), and the causes of infertility were male factors in 24 (68.6%), unexplained in five (14.3%), ovulatory factor in two (5.6%), endometriosis in two (5.6%), tubal factor in one (2.9%), and preimplantation genetic diagnosis (PGD) in one (2.9%). In the control group, the types of infertility were primary in 14 (40%) and secondary in 21 (60%), and the causes of infertility were male factors in 21 (60%), unexplained in three (8.6%), ovulatory factor in eight (22.9%), endometriosis in one (2.8), and PGD in two (5.6%). In our study, we found that the mean endometrial thicknesses after OPU were 0.594 ± 0.089 (range: 0.4-0.7) and 0.589 ± 0.090 (range: 0.6-0.9) in the treatment and control groups, respectively (odds ratio (OR): 0.005; 95% confidence interval (CI): 0.376-0.047; P < 0.791). Before ET, the mean endometrial thicknesses were 0.86 ± 0.090 (range: 0.7-0.9) and 0.7464 ± 0.06 (range: 0.7-1) in groups A and B, respectively, (OR: 0.114; 95% CI: 0.763-0.151; P < 0.001). Of the 35 patients in each group, 12 (34.3%) and five (14.3%) had confirmed pregnancies in groups A and B, respectively (OR: 0.319; 95% CI: 0.099-1.036; P < 0.05), which is statistically significant. ConclusionAutologous PRP treatment in IVF/ICSI improves the endometrial thickness and clinical pregnancy rate.

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“…Indeed, implantation is a very complicated process regulated by a number of complex molecules such as hormones, cytokines, and growth factors which play together to induce endometrial receptivity for embryo at blastocyst stage [18]. Growing data show that PRP infusion is an effective approach for the improvement of pregnancy outcomes in the patients undergoing IVF/ICSI cycles, mostly in women who were not able to respond to the standard treatment [12,19,20]. Since various studies have demonstrated that the expression of growth factors in the endometrium of women with RIF is less than normal fertile women, local infusion of PRP which contains several growth factors and cytokines may improve endometrial receptivity and embryo implantation [18,21].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Autologous Platelet-Rich Plasma on Pregnancy Outcomes in Repeated Implantation Failure Patients Undergoing Frozen Embryo Transfer: A Randomized Controlled Trial

et al. 2021

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Repeated implantation failure (RIF) is a disorder in which good-quality embryos fail to implant in the endometrium following several in vitro fertilization (IVF) cycles. This study aimed to evaluate the efficiency and safety of intrauterine infusion of plateletrich plasma (PRP) in improvement of pregnancy outcomes in RIF patients undergoing frozen embryo transfer (FET). A total of 438 women with a history of RIF undergoing FET were assessed for eligibility to enter the study. Patients were randomly assigned to the intervention (PRP) and control groups. The intervention group received an intrauterine infusion of 0.5 ml PRP 48 h before embryo transfer while the control group received standard treatment. The rates of chemical and clinical pregnancy were defined as the primary outcome values. All women were followed up until the study endpoints that included the number of neonates born and pregnancy-related complications. Three hundred and ninety-three participants accomplished the study and their data were analyzed. The chemical pregnancy, clinical pregnancy, and live birth rates were higher in the PRP group than control group (p value: <0.0001; p value: <0.0001; p value: <0.0001 respectively). However, there were no significant differences between the two groups in terms of multiple pregnancies and pregnancy complications except for spontaneous abortion. The spontaneous abortion rate was significantly higher in the control group compared to the PRP group (p value = 0.0262). These results suggest that intrauterine infusion of PRP is an effective and safe route to improve pregnancy outcomes in RIF patients undergoing FET.

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The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

Cited by 24 publications

References 44 publications

Intrauterine Perfusion of Autologous Platelet-Rich Plasma Before Frozen-Thawed Embryo Transfer Improves the Clinical Pregnancy Rate of Women With Recurrent Implantation Failure

Intrauterine Perfusion of Autologous Platelet-Rich Plasma Before Frozen-Thawed Embryo Transfer Improves the Clinical Pregnancy Rate of Women With Recurrent Implantation Failure

The Effect of Autologous Platelet-Rich Plasma Treatment on In Vitro Fertilization/Intracytoplasmic Sperm Injection and Its Impact on the Endometrium and Clinical Pregnancy Rate

The Effects of Autologous Platelet-Rich Plasma on Pregnancy Outcomes in Repeated Implantation Failure Patients Undergoing Frozen Embryo Transfer: A Randomized Controlled Trial

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