The Effect of Autologous Platelet-Rich Plasma Treatment on In Vitro Fertilization/Intracytoplasmic Sperm Injection and Its Impact on the Endometrium and Clinical Pregnancy Rate

Abduljabbar, Hassan; Hashim, Howida; Abduljabar, Hanin H; Elnaeim, Amal A; Abduljabar, Najwan H

doi:10.7759/cureus.27913

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…However, it is important to acknowledge this study's limitations, including the relatively small number of patients involved, as it is a single-center study [12,34,35].…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP

Zaha,

Huniadi,

Bodog

et al. 2023

JPM

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(1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP have been shown in recent research to have positive effects on the endometrium. PRP increases the pregnancy rate in IVF patients with thin endometrium and recurrent implantation failure. In order to demonstrate the efficacy of PRP therapies, this work compares the administration of injectable and infusible PRP during endometrial preparation. (2) Methods: This prospective single-arm control study was conducted at an IVF center in Oradea, Romania. This study included 50 patients; 27 were included in the group with Injectable PRP and 23 in the group with Infusible PRP. The outcome was compared between the two groups, with the primary outcome being the endometrial thickness after the PRP infusion or injection and the secondary outcome being the pregnancy rate in both groups. (3) Results: Patients who were treated with Injectable PRP had a higher pregnancy rate. An improvement in the quality of the endometrium, in terms of thickness, was also observed in the patients who were injected with PRP. (4) Conclusions: Compared to PRP infusions inside the uterus, sub-endometrial PRP injections in frozen embryo transfer methods have a greater pregnancy rate.

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“…However, it is important to acknowledge this study's limitations, including the relatively small number of patients involved, as it is a single-center study [12,34,35].…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP

Zaha,

Huniadi,

Bodog

et al. 2023

JPM

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A Novel Technique- Subendometrial Autologous Platelet Rich Plasma Injection in Patients with Unresponsive Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: A prospective cohort study.

Cakiroglu,

Tohma,

Yuceturk

et al. 2024

Preprint

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Background: The purpose of this study was to investigate the effects of subendometrial PRP injection on endometrial thickness and pregnancy outcomes in patients with a history of unresponsive thin endometrium undergoing frozen-thawed embryo transfer (FET). Methods: This prospective cohort study was conducted at a Acibadem Mehmet Ali Aydinlar University-Istanbul, Turkey. Women with a history of suboptimal endometrial proliferation (< 7 mm) were offered to participate in the study. Those who accepted subendometrial PRP injection formed Group 1 (n = 100); those who did not accept PRP injection formed the control group (Group 2; n = 100). Autologous PRP was prepared by centrifugation from peripheral blood and was injected transvaginally into the subendometrial region under ultrasound guidance within 10 days of the cessation of the menstruation. On the 2-4th days of the second menstrual cycle after the PRP procedure, hormonal treatment was initiated with 14 days of oral estradiol supplementation. Embryo transfer was scheduled for women who were found to have adequate endometrial thickness after the initiation of progesterone. Pregnancy (positive serum hCG) and livebirth rates were followed. Results A total of 200 women (age 36.4 ± 5.8) were included in the study. PRP treatment resulted in higher endometrial thickness compared to the control group (7.7 ± 1.9 mm vs 6.1 ± 1.2 mm; p < 0.01). In the PRP group, 3 women (3.0%) conceived spontaneously and 97 (97.0%) attempted FET; in the control group there were no spontaneous pregnancies. In the PRP group, 33/97 women (34.0% of total) could not undergo ET due to persistent unresponsive thin endometrium or fluid in the endometrial cavity, compared to 75/100 (75% of total) in controls (p < 0.001). Positive serum hCG test was significantly higher in the PRP group compared to the control group (25.8% vs 9.0%; p = 0.002). Clinical pregnancy rate was also higher in the PRP group (22.7% vs. 7.0%; p = 0.002). Live birth rate was significantly higher in the PRP group compared to the controls (17.5% vs. 2.0%; p < 0.001). Conclusions In women with a history of suboptimal endometrial development, subendometrial PRP injection was associated with improved endometrial thickness and livebirth rate. Trial registration: Acibadem Mehmet Ali Aydinlar University institutional review board and ethics committee (KA-20/23) http://www.Clinicaltrials.gov , (NCT04424160), 2020.06.15

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Platelet-Rich Plasma With an Activator: A New Approach for Treating Thin Endometriums of Women Suffering From Infertility

Nawale,

More,

Choudhary

et al. 2024

Cureus

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This case study reflects the primary infertility treatment which was in vitro fertilization (IVF) that lasted for four years. This case study involves a 37-year-old female who underwent intrauterine insemination (IUI), recurrent implantation failure, and frozen embryo transfers with a focus on platelet-rich plasma (PRP) for receptor endometrial thickness. The patient's report revealed a hormonal imbalance and a thin endometrium measuring 5 mm, while her husband's semen analysis findings were normal. Activation with calcium chloride PRP therapy successfully helped to achieve an endometrial thickness of 7.1 millimeters, and then, on the second day of the menstrual cycle, gonadotropin-releasing hormone (GnRH) was given. Six oocytes were retrieved, and after intracytoplasmic sperm injection (ICSI), a good-quality blastocyst was developed. On day 21 of the cycle, an embryo of 4AB grade was transferred. Serum beta-human chorionic gonadotropin (β-hCG) was positive, which confirmed pregnancy 14 days after the process of embryo transfer. The patient was advised to take regular check-ups during pregnancy. Recurrent implantation failure and thin endometrium are critical issues in this case, demonstrating that PRP can be used to augment the endometrial thickness to improve the pregnancy rate.

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The Effect of Autologous Platelet-Rich Plasma Treatment on In Vitro Fertilization/Intracytoplasmic Sperm Injection and Its Impact on the Endometrium and Clinical Pregnancy Rate

Cited by 3 publications

References 13 publications

Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP

Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP

A Novel Technique- Subendometrial Autologous Platelet Rich Plasma Injection in Patients with Unresponsive Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: A prospective cohort study.

Platelet-Rich Plasma With an Activator: A New Approach for Treating Thin Endometriums of Women Suffering From Infertility

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