Single Gold Nanostars Achieve Inherent Cascade Catalytic and Near-Infrared Photothermal Activities for Efficient Tumor Therapy

Abstract

Gold nanoparticles (Au NPs) used as photosensitizers for photothermal therapy (PTT) have attracted extensive attention. However, limited tissue penetration of light seriously hinders the practical application, causing Au NPs to be combined with multiple theranostic agents to improve the treatment effect. Herein, we fabricate one potent gold nanostars (GNS) that can unify the dual nanozyme activities and photothermal property, achieving effective synergistic cascade catalytic and photothermal therapy. Notably, GNS is prepared by a green and facile one-step synthesis method using biodegradable poly­(γ-glutamic acid) as a medium. The single GNS exhibits inherent dual nanozyme activities, glucose oxidase- and peroxidase-like activities, which not only convert glucose of tumor tissue into hydrogen peroxide (H2O2) but also catalyze H2O2 to produce the amount of toxic hydroxyl radicals (•OH), leading to an amplified cascade catalytic therapy. Moreover, the cascade catalytic activity of GNS is enhanced 1.4-fold in the photothermal effect. Finally, the GNS can achieve photoacoustic imaging-guided efficient synergistic cascade catalytic and photothermal therapy with a high antitumor rate of 97.0%. This simple but multifunctional GNS could provide a new strategy facilitating the practical treatment application of single Au NPs.

Feathery Tellurium–Selenium Heterostructural Nanoadjuvant for the Synergistic Treatment of Bacterial Infections

“…As predicted, the heating–cooling and linear-fitting curves of TeSe HNDs yielded a photothermal conversion efficiency of about 70.1% (Figure c). Additionally, it was higher than other photothermal agents such as MXene nanosheets (36.5%), gold nanoparticles (35.7%), and SnSe nanomaterials (41.4%) . Moreover, TeSe-ICG had superior PTT efficacy and 1 O 2 generation capacity compared to unadorned TeSe HNDs in Figures d–f, S14, and S15.…”

pH/thermal dual-responsive multifunctional drug delivery system for effective photoacoustic imaging-guided tumor chemo/photothermal therapy

“… 3,4 With the rapid development of nanomedicine, a wide variety of photothermal agents are developed for tumor therapy, including carbon nanomaterials, 5,6 noble metal, 7,8 metal sulfide, 9–11 and organic nanomaterials. 12,13 Among them, gold nanomaterials such as gold nanoparticles (AuNPs), 14,15 gold nanorods (AuNRs), 16,17 gold nanocages (AuNCs), 18,19 gold nanostars, 20,21 gold nanoshell, 22,23 and gold nanoflowers 24,25 have been extensively explored as photothermal agents for cancer therapy.…”

An additive‐free electrosynthesis of gold micro‐stars for sensitive electroanalysis of N‐Acetyl‐L‐cysteine compared to conventional gold nanoparticles

“…Anisotropic gold nanostructures are materials of interest due to their widespread applications in health, energy, and the environment. [1][2][3][4][5][6] Among different anisotropic gold nanostructures, gold nanostars have been successfully used in catalysis, [7,8] surface-enhanced Raman scattering, [9][10][11][12][13] photothermal therapy, [14][15][16] direct elec-acid [17,19,24,25] in either the absence or presence of surfactants such as sodium dodecyl sulfate, [9] poly(N-vinylpyrrolidone), [10,23,26] cetyltrimethylammonium bromide, [12,16,[27][28][29] lauryl sulfobetaine, [30] etc. and a singlestep method by using catechol, [31] hydroquinone, [11] hydroxylamine, [32,33] 2-[4-(2-hydroxyethyl)−1-piperazinyl] ethanesulfonic acid, [14] etc.…”

“…Anisotropic gold nanostructures are materials of interest due to their widespread applications in health, energy, and the environment. [ 1–6 ] Among different anisotropic gold nanostructures, gold nanostars have been successfully used in catalysis, [ 7,8 ] surface‐enhanced Raman scattering, [ 9–13 ] photothermal therapy, [ 14–16 ] direct electron transfer to biomolecules, [ 17 ] and sensors [ 18–20 ] owing to high edge densities, sharp corners and stepped atoms at the branches of the star. The utilization and application of the anisotropic gold nanostructures including star shapes are highly influenced by their method of synthesis.…”