Single laser trapping for optical folding and rotation of red blood cells in sickle cell disease in response to hydroxyurea treatment

We consider the effect of a tightly focused laser beam with a wavelength of 1064 nm and a power from 10 to 160 mW on red blood cells during their optical trapping with optical tweezers. It is found that the shape of a red blood cell, which alters after optical trapping, ceases to change when the trapping duration is less than 5 min and the laser beam power is less than 60 mW. At a beam power above 80 mW, the red blood cell begins to fold at a trapping duration of about 1 min, and at powers above 100-150 mW, the red blood cell membrane ruptures in 1-3 min after optical trapping. It is also found that with repeated short-term capture of a red blood cell in an optical trap, the deformation properties of the membrane change: it becomes more rigid. The obtained results are important both for understanding the mechanisms of interaction of a laser beam with red blood cells and for optimising the technique of optical experiments, especially for measuring the deformation properties of a membrane using optical tweezers.

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Red blood cell in the field of a beam of optical tweezers

Ermolinskiy¹,

Луговцов²,

Semenov³

et al. 2022

Quantum Electron.

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Single laser trapping for optical folding and rotation of red blood cells in sickle cell disease in response to hydroxyurea treatment

Cited by 1 publication

References 23 publications

Red blood cell in the field of a beam of optical tweezers

Red blood cell in the field of a beam of optical tweezers

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