In this work, we have proposed and optimized a segmented cladding fiber (SCF) with a large mode area (LMA) consisting of a uniform core and a double cladding. The outer cladding of the SCF consisted of a periodic alternation of high- and low-refractive-index segments, while the inner cladding consisted of a resonant layer of rods surrounded by high-refractive-index rings. The three geometrical parameters chosen as design variables were the (a) doped rod refractive index differences, (b) refractive index differences of rings, and (c) ring thickness. Using the Box–Behnken approach, we selected thirteen different design cases and modeled them numerically using the finite element method (FEM). In order to optimize the features of the proposed fiber, such as the effective mode area (EMA), we applied response surface methodology (RSM). The EMA of the optimal SCF was significantly improved and markedly enlarged to about 706 µm2 at a wavelength of 1.550 µm. Different properties of the optimized double-cladding octo-wing SCF (DC-OW-SCF), such as confinement losses in the core mode and the first higher-order mode, were studied. The DC-OW-SCF offers the advantages of feasibility in fabrication using the powder-in-tube (PIT) method and provides the possibility of utilization in compact amplifier devices and high-power fiber lasers.