Single-Neuron Correlates of Error Monitoring and Post-Error Adjustments in Human Medial Frontal Cortex

Fu, Zhongzheng; Wu, Daw‐An; Ross, Ian B.; Chung, Jeffrey M.; Mamelak, Adam N.; Adolphs, Ralph; Rutishauser, Ueli

doi:10.1016/j.neuron.2018.11.016

Cited by 104 publications

(115 citation statements)

References 91 publications

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“…As expected (Rutishauser et al, 2015;Fu et al, 2019), pooling neurons across all the brain areas we studied, the distribution of neurons was bimodal with the cutoff between the two groups equal to 0.52 ms ( Fig. 4 A, B).…”

Section: Ieds Preferentially Increase Firing Of Putative Inhibitory Nsupporting

confidence: 67%

Extent of Single-Neuron Activity Modulation by Hippocampal Interictal Discharges Predicts Declarative Memory Disruption in Humans

Reed¹,

Mosher²,

Chandravadia³

et al. 2019

J. Neurosci.

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Memory deficits are common in epilepsy patients. In these patients, the interictal EEG commonly shows interictal epileptiform discharges (IEDs). While IEDs are associated with transient cognitive impairments, it remains poorly understood why this is. We investigated the effects of human (male and female) hippocampal IEDs on single-neuron activity during a memory task in patients with medically refractory epilepsy undergoing depth electrode monitoring. We quantified the effects of hippocampal IEDs on single-neuron activity and the impact of this modulation on subjectively declared memory strength. Across all recorded neurons, the activity of 50 of 728 neurons were significantly modulated by IEDs, with the strongest modulation in the medial temporal lobe (33 of 416) and in particular the right hippocampus (12 of 58). Putative inhibitory neurons, as identified by their extracellular signature, were more likely to be modulated by IEDs than putative excitatory neurons (19 of 157 vs 31 of 571). Behaviorally, the occurrence of hippocampal IEDs was accompanied by a disruption of recognition of familiar images only if they occurred up to 2 s before stimulus onset. In contrast, IEDs did not impair encoding or recognition of novel images, indicating high temporal and task specificity of the effects of IEDs. The degree of modulation of individual neurons by an IED correlated with the declared confidence of a retrieval trial, with higher firing rates indicative of reduced confidence. Together, these data link the transient modulation of individual neurons by IEDs to specific declarative memory deficits in specific cell types, thereby revealing a mechanism by which IEDs disrupt medial temporal lobe-dependent declarative memory retrieval processes.

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Section: Ieds Preferentially Increase Firing Of Putative Inhibitory Nsupporting

confidence: 67%

Extent of Single-Neuron Activity Modulation by Hippocampal Interictal Discharges Predicts Declarative Memory Disruption in Humans

Reed¹,

Mosher²,

Chandravadia³

et al. 2019

J. Neurosci.

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“…The DAN shows domaingeneral activation (in tandem with DMN deactivation) during various conditions involving goal-oriented attention 2 . The SN shows activation during detection of salient external stimuli 66 and during behavioral errors in fMRI 67 , iEEG 68 , and single-unit recordings from key SN nodes 69 . It has been proposed that the SN, and the dAIC in particular, causally facilitates switching between other networks (including DMN and DAN) to reorient attention during salient event detection 3,5 .…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological dynamics of antagonistic brain networks reflect attentional fluctuations

et al. 2020

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Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate the behavioral relevance of fine-grained dynamics within and between these networks. The three networks show dissociable profiles of task-evoked electrophysiological activity, best captured in the high-frequency broadband (HFB; 70-170 Hz) range. On the order of hundreds of milliseconds, HFB responses peak fastest in the DAN, at intermediate speed in the SN, and slowest in the DMN. Lapses of attention (behavioral errors) are marked by distinguishable patterns of both pre-and poststimulus HFB activity within each network. Moreover, the magnitude of temporally lagged, negative HFB coupling between the DAN and DMN (but not SN and DMN) is associated with greater sustained attention performance and is reduced during wakeful rest. These findings underscore the behavioral relevance of temporally delayed coordination between antagonistic brain networks.

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“…The DAN shows domain-general activation (in tandem with DMN deactivation) during various conditions involving goal-oriented attention (Corbetta and Shulman, 2002). The SN shows activation during detection of salient external stimuli (Downar et al, 2000) and during behavioral errors in fMRI (Neta et al, 2015) and single-unit recordings from key SN nodes (Fu et al, 2018) .…”

Section: Electrophysiological Interactions Between Dan Dmn and Snmentioning

confidence: 99%

Anticorrelated inter-network electrophysiological activity varies dynamically with attentional performance and behavioral states

Kucyi

Daitch

Raccah

et al. 2018

Preprint

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The default mode network (DMN) is thought to exhibit infraslow anticorrelated activity with dorsal attention (DAN) and salience (SN) networks across various behavioral states. To investigate the dynamics of activity across these networks on a finer timescale, we used human intracranial electroencephalography with simultaneous recordings within core nodes of the three networks.During attentional task performance, the three sites showed dissociable profiles of high-frequency broadband activity. Anticorrelated infraslow fluctuations of this activity were found across networks during task performance but also intermittently emerged during rest and sleep in concert with the expression of task-like network-level topographic patterns. Critically, on a finer timescale, DAN and SN activations preceded DMN deactivations by hundreds of milliseconds.Moreover, greater lagged, but not zero-lag, anticorrelation between DAN and DMN activity was associated with better attentional performance. These findings have implications for interpreting antagonistic network relationships and confirm the behavioral importance of time-lagged internetwork interactions.

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Single-Neuron Correlates of Error Monitoring and Post-Error Adjustments in Human Medial Frontal Cortex

Cited by 104 publications

References 91 publications

Extent of Single-Neuron Activity Modulation by Hippocampal Interictal Discharges Predicts Declarative Memory Disruption in Humans

Extent of Single-Neuron Activity Modulation by Hippocampal Interictal Discharges Predicts Declarative Memory Disruption in Humans

Electrophysiological dynamics of antagonistic brain networks reflect attentional fluctuations

Anticorrelated inter-network electrophysiological activity varies dynamically with attentional performance and behavioral states

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