Single Nucleotide Polymorphism of the CYP2J2 Gene is Associated with Essential Hypertension in Uygur Population in China

Abstract

Background: Human Cytochrome P450 2J2 (CYP2J2) is the major arachidonic acid epoxygenase, which can metabolizes arachidonic acid (AA) to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. Recently, many evidence from models and human studies suggests that variability of CYP2J2 gene plays a mechanistic role in the development of hypertension. The aim of the present study was to assess the association between the human CYP2J2 gene polymorphism and Essential Hypertension (EH) in a Han and Uygur population in China. Methods:We used two independent case-control studies: a Han population (302 EH patients and 300 control subjects) and a Uygur population (567 EH patients and 215 control subjects). All EH patients and controls were genotyped for the same three single nucleotide polymorphisms (SNPs) (rs890293, rs11572223 and rs2280275) of CYP2J2 gene by a Real-time PCR instrument. Results:In the Uygur population, the distribution of SNP3 (rs2280275) genotypes, alleles and the dominant model (CC vs CT + TT) showed a significant difference between EH and control participants (for genotype: P=0.007; for allele: P=0.001; for dominant model: P=0.002). The significant difference in dominant model was retained after adjustment for covariates (OR: 3.500, 95% confidence interval [CI]: 1.680-7.300, P=0.001). However, all the above differences were not shown in the Han population. Conclusions:The CC genotype of rs2280275 in CYP2J2 gene could be a risk genetic marker of EH and T allele may be a protective genetic marker of EH in Uygur population in China.