Single nucleotide polymorphism of transforming growth factor-β1 
and interleukin-6 as risk factors for ovarian cancer

Ahmed, Amira; Zidi, Salah; Almawi, Wassim Y.; Ghazouani, E.; Mézlini, Amel; Yacoubi-Loueslati, Besma; Stayoussef, Mouna

doi:10.5114/ceji.2020.101242

Cited by 6 publications

(1 citation statement)

References 60 publications

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“…In 2020, Ahmed et al published a study about the association of TGF-ß1 rs 1880242 and Il-6 SNPs in the inflammatory process in ovarian cancer recurrence. Heterozygosity of TGF-ß1 rs 1880242 indicates a decreasing risk of ovarian cancer [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Bizoń,

Awiżeń-Panufnik,

Sawicki

2023

JPM

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The lack of specific symptoms in ovarian cancer delays onset of the diagnostic process. Hence, most cases are recognized in late stages of the disease. The aim of this study was to confirm the role of Il-6 compared to other markers in diagnosis and survival in ovarian cancer. The database was collected from 13 January 2021 to 15 February 2023. In total, 101 patients with pelvic tumors with a mean age of 57.86 ± 16.39 participated in the study. In every case, CA125, HE4, CEA, CA19-9, Il-6, C-reactive protein and procalcitonin measurements were taken. Patients with ovarian borderline tumor and metastatic ovarian tumors were excluded from further analysis. Statistically significant correlations were found between diagnosis of ovarian cancer and levels of CA125, HE4, CRP, PCT and Il-6. Comparison of Il-6 with other markers revealed that longer overall survival correlated with lower values of Il-6. In the case of a higher concentration of Il-6, OS and PFS were shorter. Sensitivity and specificity of Il-6 in diagnosis of ovarian cancer were 46.8% and 77.8%, respectively, while for CA125, CRP and PCT were 76.6% and 63%; 68% and 57.5%; 36% and 77%, respectively. More investigations are needed to identify the most specific and sensitive marker for ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Bizoń,

Awiżeń-Panufnik,

Sawicki

2023

JPM

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Sensitive electrochemical detection of polymorphisms in IL6 and TGFβ1 genes from ovarian cancer DNA patients using EcoRI and DNA hairpin-modified gold electrodes

Meftah

Habel²,

Baachaoui³

et al. 2022

Microchim Acta

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Decreased risk of ovarian cancer associated with rs9898876 sex hormone-binding globulin gene variant

et al. 2022

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Background. Ovarian cancer (OC) is one of the most common gynecologic cancers,with signi cant morbidity and mortality. The risk of OCis in uenced by hormone status, of which sex hormone-binding globulin (SHBG), whichin uences the serum availability of steroid sex hormones, is implicated in the pathogenesis and evolution of OC. The aim of this study is to evaluate the involvement of common SHBG gene variants in OC susceptibility and evolution.Materials. A case control study including 71 OC patients and 74 cancer-free controls, who were genotyped for rs9898876, rs13894, rs1799941 and rs6257 SHBG SNP. Genotyping was done by the allelic discrimination method, using VIC-and FAM-labeled primers.Results. The minor allele frequencies of rs9898876, rs13894, rs1799941 and rs6257 SHBG SNP was comparable between OC cases and control women, implying no signi cant associations of the tested variants and overall OC risk. Taking homozygous wild-type genotype as reference (OR=1.00), heterozygous rs9898876 (G/T), and minor allele-carrying genotypes [G/T+T/T] were associated with reduced risk of OC. Whilers9898876 heterozygosity (G/T) was predictive of OC occurrence, no signi cant association of the remaining three tested SNPs was noted with altered risk of OC. Irrespective of FIGO staging, the four tested SHBG SNPs were not associated with the clinical progression of OC. Conclusion.In conclusion, SHBG rs9898876 is associated with a decreased risk of OC, and thus constitutes a potential diagnostic biomarker of OC.

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Single nucleotide polymorphism of transforming growth factor-β1 and interleukin-6 as risk factors for ovarian cancer

Cited by 6 publications

References 60 publications

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Sensitive electrochemical detection of polymorphisms in IL6 and TGFβ1 genes from ovarian cancer DNA patients using EcoRI and DNA hairpin-modified gold electrodes

Decreased risk of ovarian cancer associated with rs9898876 sex hormone-binding globulin gene variant

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