Single-nucleotide polymorphism rs731384 is associated with plasma lipid levels and the risk of coronary artery disease in Chinese populations

Zhao, Cheng; Ji, Minjun; Zhang, Jing; Jia, Qiaowei; Liu, Jie-Yin; An, Feng-Hui; Chen, Zhaohong; Li, Lihua; Wang, Liansheng; Ma, Wei; Yang, Zhaohui; Jia, En-Zhi

doi:10.1042/bsr20181502

Cited by 3 publications

(1 citation statement)

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“…We found that almost all the SNPs were located at the potential functional regions, indicating that these SNPs might affect the biogenesis and expression of miRNAs. [27][28][29][30][31][32] It is attractive to propose that polymorphism in a miR-23a gene sequence may reveal a new carcinogenic mechanism. In this study, we analyzed the association between miR-23a polymorphism and the risk of PCa.…”

Section: Discussionmentioning

confidence: 99%

Association of Hsa-miR-23a rs3745453 variation with prostate cancer risk among Chinese Han population

Zhang

Wang

et al. 2019

Medicine

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Prostate cancer (PCa) is a frequently diagnosed malignant solid tumor in men. The etiology of PCa has been attributed to both environmental and genetic factors. In recent years, many studies have reported that miRNA gene single-nucleotide polymorphisms (SNPs) influence the susceptibility to several diseases such as cancer. To date, the mechanisms of PCa have remained unknown. The main aim of this study was to evaluate the association between PCa susceptibility and miRNA gene SNPs. A total of 156 PCa cases and 188 control subjects were included in this case-control study. The data were collected from hospitalized cases. We collected the demographic characteristic information, which included age, body mass index, tobacco smoking, alcohol consumption, and family history of cancer. Polymorphisms were analyzed by the ligase detection reaction. Unconditional logistic and stratified analyses were used to analyze the association between these SNPs and PCa susceptibility and to calculate the adjusted odds ratios (ORs) and the 95% confidence intervals (CIs). Cox regression model and the log-rank test were used to test the association between genetic variants and the overall survival. We found that miR-23a gene polymorphism rs3745453 carrying CC homozygotes had a 4.16-fold increased risk (95% CI = 1.30-13.25) than those carrying the TT/CT genotypes (P = .02), and the C allele displayed a higher prevalence of PCa than the T allele (OR = 1.68, 95% CI = 1.16-2.45, P = .01). Moreover, miR-23a showed that the homozygous carriers of the C-variant significantly increased the risk of survival rate as compared to the carriers of the TT/CT genotype (OR = 9.67, 95% CI = 2.83-33.09, P = .001). The rs3745453 polymorphism was potentially associated with PCa in the Chinese Han population and had an interactive relationship with the environmental factors.Abbreviations: BMI = body mass index, 95% CI = 95% confidence interval, LDR = ligase detection reaction, MAF = minor allele frequency, MRI = magnetic resonance imaging, ORs = odds ratios, PCa = prostate cancer, SNP = single-nucleotide polymorphism, TNM = tumor node metastasis.

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Section: Discussionmentioning

confidence: 99%

Association of Hsa-miR-23a rs3745453 variation with prostate cancer risk among Chinese Han population

Zhang

Wang

et al. 2019

Medicine

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Hearing impairment and diverse health outcomes

Trott

Smıth

Xiao

et al. 2021

Wien Klin Wochenschr

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Background: Globally, it is estimated that approximately 1.3 billion people live with some form of hearing impairment. Major causes of hearing loss include infection/disease, age-related factors, and occupational factors. Numerous systematic reviews and meta-analyses have attempted to synthesise literature on these topics. To date there has not been a systematic evaluation of the relationships between hearing impairment and diverse physical, mental, and social outcomes.Objective: We performed an umbrella review of systematic reviews of observational studies with meta analyses for any physical disease, biomarkers of disease, mental health or cognitive outcomes, and/or modifiable risk factors associated with hearing impairment. Methods:For each meta-analytic association, random-effects summary effect size, 95% confidence intervals, heterogeneity, evidence for small-study effect, excess significance bias and 95% prediction intervals were calculated, and risk of bias was assessed via the AMSTAR2 tool. These were used to grade significant evidence (p<0.05) from I to IV, using the recommendations from the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.Results: From 3,747 studies, 21 were included covering 54 outcomes. Overall, 44/54 outcomes (82%) yielded significant results. Of the highest quality evidence, age related hearing loss and non-specific hearing impairment was negatively associated with several types of cognitive impairments; paediatric bilateral hearing loss was negatively associated with quality of life; sensorineural hearing loss was

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The Association Between Extracellular Matrix Metalloproteinase Inducer Polymorphisms and Coronary Heart Disease: A Potential Way to Predict Disease

Weng

Chen

Ren

et al. 2020

DNA and Cell Biology

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Single-nucleotide polymorphism rs731384 is associated with plasma lipid levels and the risk of coronary artery disease in Chinese populations

Cited by 3 publications

References 33 publications

Association of Hsa-miR-23a rs3745453 variation with prostate cancer risk among Chinese Han population

Association of Hsa-miR-23a rs3745453 variation with prostate cancer risk among Chinese Han population

Hearing impairment and diverse health outcomes

The Association Between Extracellular Matrix Metalloproteinase Inducer Polymorphisms and Coronary Heart Disease: A Potential Way to Predict Disease

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