Single-nucleotide polymorphisms g.151435C&gt;T and g.173057T&gt;C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats

An, Xiaopeng; Hou, Jinxing; Gao, Teyang; Yue, Lei; Li, Guang; Song, Yuxuan; Wang, Jiangang; Cao, Binyun

doi:10.1016/j.theriogenology.2015.01.030

Cited by 32 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymorphisms of GNRH1 and GDF9 genes were identified, and their association with litter size in goats was analyzed (An et al, 2013a). The SNPs of the PRLR gene regulated by bta-miR-302a associated with litter size in goats were analyzed (An et al, 2015b). The genetic polymorphisms of KITLG gene were explored, and the results indicated that three SNPs may play an important role in litter size (An et al, 2013b;Wang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

et al. 2018

View full text Add to dashboard Cite

Abstract. The LIM homeobox transcription factor 4 (LHX4) gene plays a critical role in regulating the development of the pituitary and the secretion of growth hormone (GH) and prolactin (PRL) associated with reproduction. Thus this gene may affect litter size. Herein, the aim of this study is to detect the novel insertion/deletion (indel) within the LHX4 gene as well as to test its association with litter size in 1149 Shaanbei white cashmere goats. Herein, a novel 12 bp indel (NC_030823.1:g.60001011_60001022delGGGGAGGAGGGG) was firstly found, which was located in the first intron. Meanwhile, three genotypes were detected in Shaanbei white cashmere goats, and the allelic frequencies of I and D were 0.593 and 0.407, respectively. Interestingly, the genotype distributions between mothers of single-lamb (n = 895) and multi-lamb (n = 254) groups within Shaanbei white cashmere goats were significantly different, implying that the 12 bp indel might affect the litter size. Furthermore, the association analysis was carried out to find out that the 12 bp indel was significantly associated with litter size in the analyzed goat population (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II (P < 0.05). These findings suggest that this locus could be considered as a genetic marker for goat breeding, enriching the research category of functional genome of goats.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Single nucleotide polymorphisms (SNPs) represent the most abundant form of DNA variation in animal genome [17]. Common SNPs of miRNA precursors interfere with miRNA function by altering miRNA expression or maturation, resulting in phenotypic variation, including disease susceptibility.…”

Section: Introductionmentioning

confidence: 99%

“…Bartz et al [20] reported that polymorphism of the porcine miR-30d was associated with adipose tissue accumulation, its fatty acid profile and the malic enzyme 1 ( ME 1 ) gene expression. An et al [17] reported that single-nucleotide polymorphisms g.151435C>T and g.173057T>C in prolactin receptor ( PRLR ) gene regulated by bta-miR-302a were associated with litter size in goats. Gga-miRNA-133a and gga-miR-1a were reported to be related to skeletal muscle, whereas gga-miR-122 was adipose-related miRNA in chickens [21].…”

Section: Introductionmentioning

confidence: 99%

Effect of pre-miRNA-1658 gene polymorphism on chicken growth and carcass traits

Jian-zhou

Sun

2016

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

ObjectivePolymorphisms occurring in the precursor region of microRNAs (miRNAs) affect the target gene and alter the biogenesis of miRNAs, resulting in phenotypic variation. The purpose of the study was to investigate the genetic effects of rs16681031 (C>G) mutation in the precursor region of gga-miR-1658 on the economic traits of the Gushi-Anka chicken F2 resource population.MethodsTo explore the effect of miR-1658 polymorphisms on chicken economic traits, the SNP was genotyped by MassArray matrix-assisted laser desorption/ionization-time of flight mass spectrometry. The association between the SNP and chicken body size, growth and carcass traits was determined by linear mixed models.ResultsThe SNP was not only significantly associated with body weight at the age of 6, 8, 10, 12 weeks, respectively, but also with the breadth of the chicken chest, body slanting length and pelvic breadth at 4 weeks, chest depth at 8 weeks of age, and body slanting length at 12 weeks (p<0.05), respectively.ConclusionOur data serve as a useful resource for further analysis of miRNA function, and represent a molecular genetic basis for poultry breeding.

show abstract

“…A previous study demonstrated that a non-synonymous SNP G1534A mutation in exon 2 of bone morphogenetic protein 4 (BMP4) within the India goat breeds Black-Bengal and Jakhrana are related to variations seen in prolificacy8. Similarly, two homozygous SNPs (g.151435C > T, g.173057T > C) located in exon 2 and the 3′ untranslated region (3′ UTR) of the prolactin receptor (PRLR) gene are significantly associated with fecundity in both Guanzhong and Boer goat breeds9. Furthermore, it has been found that heterozygous SNPs g.224 A > G and g.227 C > T in the 5′ flanking region in insulin-like growth factor 1 (IGF1) is associated with LS10.…”

mentioning

confidence: 99%

Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus)

Lai

Zhai²,

Cheng

et al. 2016

Sci Rep

101

View full text Add to dashboard Cite

Dairy goats are one of the most utilized domesticated animals in China. Here, we selected extreme populations based on differential fecundity in two Laoshan dairy goat populations. Utilizing deep sequencing we have generated 68.7 and 57.8 giga base of sequencing data, and identified 12,458,711 and 12,423,128 SNPs in the low fecundity and high fecundity groups, respectively. Following selective sweep analyses, a number of loci and candidate genes in the two populations were scanned independently. The reproduction related genes CCNB2, AR, ADCY1, DNMT3B, SMAD2, AMHR2, ERBB2, FGFR1, MAP3K12 and THEM4 were specifically selected in the high fecundity group whereas KDM6A, TENM1, SWI5 and CYM were specifically selected in the low fecundity group. A sub-set of genes including SYCP2, SOX5 and POU3F4 were localized both in the high and low fecundity selection windows, suggesting that these particular genes experienced strong selection with lower genetic diversity. From the genome data, the rare nonsense mutations may not contribute to fecundity, whereas nonsynonymous SNPs likely play a predominant role. The nonsynonymous exonic SNPs in SETDB2 and CDH26 which were co-localized in the selected region may take part in fecundity traits. These observations bring us a new insights into the genetic variation influencing fecundity traits within dairy goats.

show abstract

Single-nucleotide polymorphisms g.151435C>T and g.173057T>C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats

Cited by 32 publications

References 25 publications

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

Effect of pre-miRNA-1658 gene polymorphism on chicken growth and carcass traits

Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus)

Contact Info

Product

Resources

About

Single-nucleotide polymorphisms g.151435C>T and g.173057T>C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats

Cited by 32 publications

References 25 publications

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

Effect of pre-miRNA-1658 gene polymorphism on chicken growth and carcass traits

Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus)

Contact Info

Product

Resources

About

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size