Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma

Naykoo, Niyaz A.; Dil-Afroze,; Rasool, Roohi; Shah, Sonaullah; Ahangar, Abdul Gani; Bhat, Imtiyaz Ahmad; Qasim, Iqbal; Siddiqi, Mushtaq A.; Shah, Zafar A.

doi:10.1016/j.gene.2017.01.007

Cited by 29 publications

(12 citation statements)

References 47 publications

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“…Platelets have been studied for decades as an important regulator of inflammation and thrombosis (34), which are broadly interrelated with human carcinogenesis (13). Platelets are also recognized as a stimulator of proangiogenic factors (13) and a major source of VEGF (35), platelet-derived growth factor (36,37), and basic fibroblast growth factor (37), which act as promoters of tumor growth in lung (38)(39)(40)(41)(42)(43)(44). New evidence suggests that platelets are relevant to defensive, physiologic immune responses of the lungs and to inflammatory lung diseases (45).…”

Section: Discussionmentioning

confidence: 99%

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu

Wei

Zhang

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings.Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention.Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

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Section: Discussionmentioning

confidence: 99%

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu

Wei

Zhang

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Currently, genotyping single nucleotide polymorphism (SNPs) of a population and comparing the distribution frequency of SNPs among subgroups (for example, controls and patients) is frequently used to examine the risk and prognosis of a cancer 4 . Emerging reports indicate an association between SNPs in certain genes and lung cancer progression, as for instance, specific SNP variants within the vascular endothelial growth factor, the interleukin-32 ( IL-32 ) and the PARK2 genes 5 - 7 .…”

Section: Introductionmentioning

confidence: 99%

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Liu¹,

Yang²,

Chen³

et al. 2017

Int. J. Med. Sci.

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Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population.

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“… 4 Vascular endothelial growth factor is known as a lymphangiogenic growth factor and plays an important role in tumor lymphangiogenesis via activation of the VEGF receptor. 5 Present data indicate that VEGF gene polymorphisms were associated with the risk of cancers, such as bladder cancer, 6 papillary thyroid carcinoma, 7 lung cancer, 8 hepatocellular carcinoma, 9 and renal cell carcinoma. 10 The VEGF pathway also plays a prominent role in the growth and progression of human cancer, including gastric cancer.…”

Section: Introductionmentioning

confidence: 89%

Association of Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms With Gastric Cancer and Its Development, Prognosis, and Survival

Liu

Dong

et al. 2018

Technol Cancer Res Treat

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The relationship between vascular endothelial growth factor gene polymorphism and gastric cancer risk and its development, prognosis, and survival are still being debated. This meta-analysis was performed to assess these relationships. The association reports were identified from PubMed, Embase, Cochrane Library, and CBM-disc (China Biological Medicine Database), and eligible studies were included and calculated using the meta-analysis method. VEGF+936C/T, VEGF+405 G>C, VEGF-460 T>C, VEGF-1498 T>C, and VEGF-2578 C>A gene polymorphisms were found to be unassociated with gastric cancer risk for the overall population in this meta-analysis, whereas the VEGF-634 G>C GG genotype was associated with gastric cancer risk in the overall population. Furthermore, VEGF-634 G>C C allele and the GG genotype were associated with gastric cancer risk in Caucasians, and VEGF+1612G/A gene polymorphism was associated with gastric cancer risk for the Asian population. VEGF+936C/T gene polymorphism was not associated with the stage of cancer, lymph node metastasis, Lauren classification, or survival of gastric cancer. However, VEGF+936C/T T allele and TT genotype were associated with the tumor size of gastric cancer. In conclusion, the VEGF-634 G>C GG genotype was associated with gastric cancer risk in the overall population with the VEGF-634 G>C C allele and GG genotype being associated with risk in Caucasians and VEGF+1612G/A in the Asian population.

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Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma

Cited by 29 publications

References 47 publications

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Association of Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms With Gastric Cancer and Its Development, Prognosis, and Survival

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