Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption

The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk

“…The data here reported are in agreement with previews studies (for different cancer types) conducted by García-Closas et al (28), where they failed to show an association between XRCC4 Asn298Ser and breast cancer in a meta-analysis using two populationbased studies in USA and Poland; and Roddam et al (17), reporting null results for multiple myeloma and LIG4 Thr9Ile in an European population. Conversely, there are previews reports conducted by Figueroa et al (16), showing an association of XRCC4 Asn298Ser heterozygous genotype [OR=1.43 (1.14-1.80 CI), P=0.002, n (cases) = 21% vs. n (controls) = 16%] with bladder cancer risk in a Spanish population; Werbrouck et al (29), pointed out an association of LIG4 Thr9Ile heterozygous and variant homozygous genotypes [OR=0.5, P=0.03, n (cases )=19.7% vs. n (controls) = 28% and OR=0.12, P=0.01, n (cases) = 2% vs. n (controls) = 5.1%, respectively] with head and neck cancer in a Belgian population; Tseng et al (20) also reported an association between XRCC4 Asn298Ser [homozygous variant OR = 2.38 (1.05-5.76 CI), P=0.043, n (cases) = 12.7% vs. total n (controls) = 5.96%] and LIG4 Thr9Ile [heterozygous and homozygous variant association OR = 1.64 (1.03-2.62 CI), P=0.038] with lung cancer in a Chinese population. This disparity of results found might be due to different risk factors in the assorted populations and/or differences in the genetic background.…”

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

“…XRCC3 gene participates in the repair of DNA double-strand breaks, which is the most common lesion in the genome and can occur as a result of multiple damaging agents, such as ionizing radiation or chemical exposure (Ataian et al, 2006). The accurate functioning of DNA repair proteins is a crucial step in maintaining genomic homeostasis and preventing carcinogenesis (Werbrouck et al, 2008), and polymorphisms in repair genes could alter an individual susceptibility to cancer.…”

The Cys326 Allele of the 8-Oxoguanine DNA N-Glycosylase 1 Gene as a Risk Factor in Smoking- and Drinking-Associated Larynx Cancer

“…In other words, there might not be a substantial difference between some of the "moderate smoking" and "never-smoking" individuals. We chose patients with larynx cancer because it was showed in the studies linking anatomical regions of HNC, that larynx was the most sensitive region for smoking-related cancer (Werbrouck et al 2008).…”