Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population

Abstract

It is known that increased plasma levels of inflammatory markers, such as interleukin-6 (IL-6

Interleukin-6 -634C>G polymorphism in hypertensive patients with and without left ventricular hypertrophy

“…The present findings are in agreement with existing reports from multiple studies conducted in Chinese and other populations (6,15,16,26,27). Although the mechanism remains unclear, studies have shown that the influence of the IL-6 polymorphism on blood pressure differs according to gender (13,14). Thus, we further investigated the genotype and allele frequency distribution and blood pressure values according to genotype by gender.…”

“…An association between the -174G>C polymorphism and systolic blood pressure (SBP) as well as diastolic blood pressure (DBP) was found in middle-aged healthy Caucasian men (13). However, the -174G>C polymorphism is recognized with only low allele frequency in eastern Asian populations (6,(14)(15)(16).…”

Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

“…The IL-6 gene is located at p21 of chromosome 7, contains a 1.3 kb coding sequence with five exons and encodes a 23.7 kd protein. It is a polymorphic gene which -634 C/G, -598 A/G, -597 G/A, -572 G/C, -174 G/C polymorphisms were identified in its promoter region (Wang et al 2011;Nakajima et al 1999;Sesso et al 2006;Gao et al 2011;Jenny et al 2002;Baumann and Gauldie 1994;Wypasek et al 2010;Tanaka et al 2005;Sanders et al 2009;Timasheva et al 2008;Kitamura et al 2002;Illig et al 2004). Therefore most of the studies on IL-6 gene focus on promoter region polymorphism analyses.…”

Betel Nut Chewing Is Associated with Hypertension in Taiwanese Type 2 Diabetic Patients

“…The production of these chemical agents might be the mediators responsible for the carcinogenicity and diabetogenicity associated with betel nut chewing. All of these chemicals are also potentially causative of hypertension and cardiovascular disease through the mechanisms of endothelial dysfunction, expression of vascular cell adhesion molecules, induction of insulin resistance and diminished fibrinolysis (38)(39)(40)(41)(42)(43).…”