Single Nucleotide Polymorphisms of Toll-Like Receptor 7 in Hepatitis C Virus Infection and Hepatocellular Carcinoma Patients

Elsedawy, Yara S.; Khattab, Mona A.; Hady, Soha Abdel; Sayed, Abeer A. El; Albreed, Ashraf M.; Hefny, Zeinab M.

doi:10.12816/0037023

Cited by 3 publications

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“…HCV ssRNA stimulation of TLR7 signalling, have been reported to reduce the HCV load in patient's sera. This suggests that genetic polymorphism of TLR7 gene may impair the immune response against HCV 12 .…”

Section: Discussionmentioning

confidence: 99%

“…TLR7 SNP rs179009 changes the nucleotide base at position 151 from G to A. It can affect the ability of infected individuals to respond effectively to TLR7 ligands, and hence may affect their susceptibility to HCV infection 12 . In this study, the SNP rs179009 was studied because TLR7 different SNP genotypes, have different influences on IFN secretion and response to IFN therapy 8 .…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the AA genotype and the A allele were dominant among HCC patients, a finding that is similar to that reported by Lin et al 23 . TLR7 polymorphism may influence HCC susceptibility because the distribution of TLR7 rs179009 was significantly different in HCC patients compared to the controls (p=0.01) 12 . It was hypothesized that IFNinduced by hepatitis virus infection may significantly decrease TLR7 promotor activity leading to downregulation of TLR7 gene expression resulting in immune escape and even immunological tolerance thereby facilitating its persistence within liver cells.…”

Section: Discussionmentioning

confidence: 99%

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Toll-like Receptor 7 Expression and Gene Polymorphism in Patients with Hepatitis C and Hepatocellular Carcinoma

Ghonaim

Aziz

Mostafa

et al. 2019

Egyptian Journal of Medical Microbiology

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Toll-like receptor-7 (TLR7) plays pivotal roles in type I interferon (IFN) secretion and protective antiviral immunity against hepatitis C virus (HCV) infection.Objectives: To assess expression levels of TLR7 in patients with hepatitis C infection and patients with hepatocellular carcinoma (HCC), to investigate possible association between TLR7 (rs179009) polymorphism and infection outcome, and to compare the expressions of TLR7 variants. Methodology: A total of 98 candidates, divided into four groups, were enrolled in this study. TLR7 mRNA expression level was determined for all participants using real-time PCR, and TLR7 single nucleotide polymorphism (SNP) rs179009 was assessed using Taq-Man SNP genotyping assay and real-time PCR. Results: TLR7 expression levels were significantly lower in patients with chronic HCV and HCC compared to patients who naturally cleared their infection and controls (P< 0.05). In females, the AA genotype and the A allele were significantly predominant in HCV clearance group (83.33%), healthy controls (78.6%) and HCC patients (75%), compared to females with chronic hepatitis (21.4%) (P< 0.05), while, the AG and GG genotypes were more commonly found in chronic HCV-infected females. However, no association was found regarding TLR7 polymorphism genotypes distribution in males and HCV susceptibility. High TLR7 expression levels were associated with the AA genotype in HCV-infected females and males. Conclusion: HCV may induce down regulation of TLR7 expression. Polymorphisms in TLR7 gene with different expression levels might affect immune response during HCV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Toll-like Receptor 7 Expression and Gene Polymorphism in Patients with Hepatitis C and Hepatocellular Carcinoma

Ghonaim

Aziz

Mostafa

et al. 2019

Egyptian Journal of Medical Microbiology

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The impact of Toll-like receptors on the immune system functioning and on the immunopathogenesis of chronic hepatitis C: a modern view (literature review)

et al. 2020

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A -research concept and design; B -collection and/or assembly of data; C -data analysis and interpretation; D -writing the article; E -critical revision of the article; F -final approval of the article There exists a considerable body of literature on immunopathogenesis of chronic hepatitis C. Although results appear consistent with prior research in the area mentioned above, they appear inconsistent with the issues in the area of diagnosis, prognosis and treatment effectiveness. In this context the study addresses the research to receptors of the innate immune system -Toll-like receptors.The aim of the research is to analyze the data of current professional literature regarding the role of individual Toll-like receptors in the immunopathogenesis of chronic hepatitis C. Materials and methods.The method of reviewing and systematizing as well as the method of content analysis were used to overview the scientific literature as for the role of Toll-like receptors. For this purpose, we employ survey data collected from the world professional literature and analyzed the results of current researches.Conclusions. The innate immune system plays a prominent role in the primary protection of the body against pathogens which recognition depends on the Toll-like receptors family wheres the genetic analysis is considered as a promising method of preventive and personalized medicine. The advantage of genetic markers regardless of age and other factors contain information about the susceptibility to multifactorial diseases which can be used to create a «genetic passport» of a person. Perceptions about the impact of the Asp299Gly polymorphism of the Toll-like receptor 4 gene and Gln11Leu of the Toll-like receptor 7 gene on the immunopathogenesis of chronic hepatitis C are ambiguous and this research provides a good starting point for discussion and further study which will allow optimizing the therapeutic and diagnostic tactics for this disease based on the complex evaluation of immunity which are defined by the determined polymorphisms.

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Prediction of Hepatic Fibrosis Progression Rate in Chronic Hepatitis C on the Basis of Clinical and Genetic Signs

Syzova

Коваль

Bodnar

et al. 2019

WOMAB

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Single Nucleotide Polymorphisms of Toll-Like Receptor 7 in Hepatitis C Virus Infection and Hepatocellular Carcinoma Patients

Cited by 3 publications

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Toll-like Receptor 7 Expression and Gene Polymorphism in Patients with Hepatitis C and Hepatocellular Carcinoma

Toll-like Receptor 7 Expression and Gene Polymorphism in Patients with Hepatitis C and Hepatocellular Carcinoma

The impact of Toll-like receptors on the immune system functioning and on the immunopathogenesis of chronic hepatitis C: a modern view (literature review)

Prediction of Hepatic Fibrosis Progression Rate in Chronic Hepatitis C on the Basis of Clinical and Genetic Signs

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