Single oral dose of chlorogenic acid attenuates the experimental carrageenan-induced oxidative stress

Mitrea, Daniela-Rodica; Malkey, Ronny; Pop, Nadina-Liana; Filip, Adriana; Clichici, Simona; Moldovan, Remus; Bidian, Cristina; Toader, Alina-Mihaela; Florian, Teodora-Larisa

doi:10.26659/pm3.2020.21.2.74

Cited by 16 publications

(21 citation statements)

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“…Concerning to antioxidants parameters, carrageenan injected rats showed a significant increase in MDA compared to rat non-treated in all check points. This result agrees with Mitrea et al (2020), who attributed that to carrageenan administration produced lipid peroxidation in kidneys. Malondialdehyde (MDA) arises due to the peroxidation of polyunsaturated fatty acids in cells (Dahiya et al, 2013).…”

Section: Discussionsupporting

confidence: 93%

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Evaluation of renoprotective and Anti-inflammatory effects of doxycycline in carrageenan-induced renal inflammation

Amin

Elshemy

Fararh

2021

Benha Veterinary Medical Journal

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The present study was designed to investigate biochemical changes induced by doxycycline treatment of carrageenan-induced renal inflammation. For this purpose, 60 rats divided into four groups. Group (1) used as a control and administrated distilled water (1 ml/kg, i. p.) daily for 5 days. Group (2) carrageenan group: rats administrated 2% λ-Carrageenan (25 µl/ kg, i. p.) as one dose at first day of experiment. Group (3) doxycycline rats were received doxycycline (100 mg/kg, i. p./day/5 days). Group (4) carrageenan+ doxycycline rats were received doxycycline (100 mg/kg, i. p.), after an hour 2% λcarrageenan (25 µl/kg, i. p.) as one dose at first day of experiment. The experiment was continued for 5 days. Collection of samples was performed on 1 st , 3 rd , and 5 th day of experiment. Serum was used for evaluation of kidney function (urea, creatinine, Na + and K + ) and plasma proteins (total protein, albumin, and globulin), as well as inflammatory markers and cytokines (TNF-α, IL-6, CRP, and NO). Kidney tissue used for estimation of antioxidant parameters (MDA and GPx), and histopathology. The results revealed that there were significant increases in urea, creatinine, MDA, TNF-α, IL-6, CRP, and NO in carrageenan group, while GPx, Na + and K + showed significant decreases. Moreover, histological examination of group 2 showed degenerative changes in the lining epithelium of renal tubules associated with peritubular mononuclear cells infiltration compared with control group. Therefore, it could be concluded that doxycycline has anti-inflammatory role.

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Section: Discussionsupporting

confidence: 93%

“…The results presented are in line with Mansouri et al (2015). Carrageenan induced inflammation in the kidney (Mitrea et al, 2020). There is also a lot of evidence that the development of ROS at the inflammation site, such as hydrogen peroxide, superoxide and hydroxyl radicals, leads to tissue damage (Cuzzocrea et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of renoprotective and Anti-inflammatory effects of doxycycline in carrageenan-induced renal inflammation

Amin

Elshemy

Fararh

2021

Benha Veterinary Medical Journal

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“…Recently, Di Wang et al (2019) reported that chlorogenic acid (100 mg/kg/day BW) taken for 4 weeks ameliorated the survival rate after myocardial infarction and demonstrated that this compound showed a protective effect on myocardial infarction by reducing inflammatory response, exerting antioxidant activity, and minimizing weight gain. Similarly, chlorogenic acid (100 or 150 mg/ day) reduced oxidative-induced damage and increased antioxidant protection in the inflamed paw skin, and reduced lipid peroxidation in serum (Mitrea et al, 2020). The effect of chlorogenic acid (100 mg/kg BW for 13 weeks) on energy balance in obese mice has been studied recently (He et al, 2020).…”

Section: Chlorogenic Acidmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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“…Figures 2 and 3 show possible modulations by CGA, although individual pathways in which CGA is involved have not necessarily been reported. Figure 2 illustrates CGA's downregulation of ROS [2,11,48,120,127], DNA damage [123], EGFR [127], Akt/phosphatidyl 3-inositol kinase (PI3K) [127], ERK1/2 [11,127], NF-κB [2,121,125,127,128], TNF-α [2,122], IL-1β [122], IL-8 [2,11], IL-6 [122], MMPs [2,11], COX-2 [125,128], Bcl-2 [10,129], mTOR [10,127], VEGF [126], and upregulation of AMPK [7,49]. Although CGA's upregulation of CaMKK and LKB1 shown in Figure 3 has not been determined yet, Park et al [130] reported upregulation of them by neochlorogenic acid, an isomer of CGA.…”

Section: Basic Research On Anti-cancer Action Of Coffee and Cgamentioning

confidence: 99%

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

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Tea and coffee are consumed worldwide and epidemiological and clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) and chlorogenic acid (CGA) are the major components of green tea polyphenols and coffee polyphenols, respectively, and believed to be responsible for most of these effects. Although a large number of cell-based and animal experiments have provided convincing evidence to support the anti-cancer effects of green tea, coffee, EGCG, and CGA, human studies are still controversial and some studies have suggested even an increased risk for certain types of cancers such as esophageal and gynecological cancers with green tea consumption and bladder and lung cancers with coffee consumption. The reason for these inconsistent results may have been arisen from various confounding factors. Cell-based and animal studies have proposed several mechanisms whereby EGCG and CGA exert their anti-cancer effects. These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. Meanwhile, EGCG and CGA have also different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies. Further studies will be necessary to clarify what is the mechanism to cause such differences between green tea and coffee.

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Single oral dose of chlorogenic acid attenuates the experimental carrageenan-induced oxidative stress

Cited by 16 publications

References 0 publications

Evaluation of renoprotective and Anti-inflammatory effects of doxycycline in carrageenan-induced renal inflammation

Evaluation of renoprotective and Anti-inflammatory effects of doxycycline in carrageenan-induced renal inflammation

Citrus species: Modern functional food and nutraceutical-based product ingredient

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

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