Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial

Somigliana, Edgardo; Sarais, Veronica; Reschini, Marco; Ferrari, Stefania; Makieva, Sofia; Cermisoni, Greta Chiara; Paffoni, A.; Papaleo, Enrico; Viganò, Paola

doi:10.1016/j.ajog.2021.04.234

Cited by 32 publications

(53 citation statements)

References 32 publications

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“…Among the remaining 12 potentially eligible records, we retrieved full-texts of 10 records because of 2 records were determined to be the conference abstract which reported insufficient information. Finally, 5 studies ( 27 – 31 ) were judged to meet our selection criteria after excluding 5 ineligible studies due to the following reasons, namely, ineligible regime (n = 1), ineligible study aim (n = 1), ineligible patients (n = 2), and unrelated to our topic (n = 1). We used Figure 1 to display the flow chart of study retrieval and selection.…”

Section: Resultsmentioning

confidence: 99%

“…Among enrolled 5 eligible studies, 3 studies ( 27 , 28 , 30 ) were performed in Iran and another 2 studies ( 29 , 31 ) were performed in Italy. The publication time of individual study ranged from 2014 to 2021.…”

Section: Resultsmentioning

confidence: 99%

“…Most eligible studies ( 27 – 30 ) enrolled inadequate sample size with a median number of 92, apart from 1 study performed by Somigliana et al. ( 31 ), in which 573 patients were included in the final analysis. Two studies ( 27 , 28 ) instructed patients to take orally vitamin D pearl capsule, 2 studies ( 29 , 31 ) instructed patients to take orally vitamin D3, and 1 study ( 30 ) instructed patients to take orally calcitriol pills.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, several systematic reviews ( 8 , 23 – 26 ) of observational studies further suggested that women with deficient or insufficient vitamin D have lower chances of IVF success, however whether vitamin D supplementation can improve IVF outcomes is still controversial. Agreeably, some randomized controlled trials (RCTs) ( 27 – 31 ) have also been performed to demonstrate the role of vitamin D in reproduction. Unfortunately, however, most of the published RCTs ( 27 – 30 ) were interventional studies with small sample size, which were underpowered to draw a definitive conclusion.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Zhou

Luo

et al. 2022

Front. Endocrinol.

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Despite numerous studies indicating an imperative role of vitamin D for reproduction, the importance of vitamin D supplementation on in vitro fertilization (IVF) outcomes remains controversial. We therefore performed this meta-analysis to investigate the IVF outcomes of vitamin D supplementation in infertile women with vitamin D deficiency. We systematically searched PubMed, Embase and the Cochrane library for identifying all relevant studies published before August 2021. Pregnancy rate was defined as the primary outcome while good quality embryo, fertilization rate, ongoing pregnancy, and miscarriage were secondary outcomes. We used Review Manager 5.3 (RevMan) to conduct meta-analysis and examined the robustness of the primary outcome by trial sequential analysis. Five studies were included in the final analysis and it suggested that vitamin D supplementation was associated with improved chemical pregnancy rate (risk ratio [RR] = 1.53, 95% confidence interval [CI] = 1.06 to 2.20, p = 0.02) but not benefited in improving clinical pregnancy rate (RR = 1.34, 95% CI = 0.81 to 2.24, p = 0.25) and all secondary outcomes. Trial sequential analysis suggested further studies are needed to confirm this conclusion. We concluded that vitamin D supplementation should be prescribed to improve chemical pregnancy in infertile women with vitamin D deficiency and more studies are required to further confirm this finding.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Zhou

Luo

et al. 2022

Front. Endocrinol.

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“…Men provided semen samples after 2 to 4 days of abstinence. IUI and IVF were standardized and performed as previously described (8)(9)(10). For IVF, oocyte collection was performed 36 h after triggering of ovulation.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Reschini

Pagliardini

Boeri

et al. 2022

Front. Public Health

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With the implementation of COVID-19 vaccine up-take, doubts regarding the impact of immunization on future fertility have begun to emerge. We have examined vaccine safety on male reproductive health. We set up a multicentre (three infertility centers), retrospective study in order to assess semen parameters and fertilization rate of one hundred-six men in a pairwise comparison between the first and second assisted reproduction technology (ART) attempt, performed respectively before and after COVID-19 vaccination. Median time (range) between the first vaccine dose and the second ART cycle was 75 days (39–112). Semen parameters did not change before and after the exposure. Fertilization rate was also similar before and after vaccination. Twenty-five patients (24%) were oligozoospermic before the vaccination while 26 (25%) after the exposure (P = 0.87). Severe asthenozoospermia were present in 11 patients before as well as after the exposure. No difference was observed even after considering different types of vaccines (mRNA or viral vector). COVID-19 vaccination did not affect sperm quality and fertilization capacity of men undergoing ART treatments and should be considered safe for men's reproductive health.

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Male and female human papilloma virus infection and assisted reproductive technology outcomes: A comprehensive assessment from prevalence in semen to obstetric outcomes

Carullo,

Uceda Renteria,

Basili

et al. 2024

Journal of Medical Virology

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Infertility, affecting approximately 16% of the global population, has led to increased reliance on reproductive medicine. The impact of human papillomavirus (HPV) infection in one or both partners on outcomes of Assisted Reproduction Technologies (ART) remains unclear. This prospective cohort study aimed to evaluate prevalence and effects of HPV infection in subjects and couples candidates to ART. A total of n = 510 men and n = 246 women were included and n = 145 couples (n = 290 individuals) had both partners enrolled in the study. The HPV semen infection rate was 17% (95% CI: 14–20) with HPV‐42, HPV‐16, HPV‐53 and HPV‐51 as the most frequently detected genotypes. In women, 26% (95% CI: 21–32) tested HPV‐positive in cervical swabs. In 6% (95% CI: 3–11) of the couples, both partners were positive but only three couples shared the same genotypes (HPV‐16; HPV‐39, HPV‐51, and HPV‐42; HPV‐31). Follicular fluids were positive in 20% (95% CI: 11–33) of samples, showing genotype discrepancies with cervical tests. Semen treatment could not completely eliminate the virus in positive samples but reduced the positivity to one‐third. No significant differences in semen and embryological variables, clinical pregnancy and live birth rates, neonatal and obstetrics outcomes were observed in subjects with positivity in semen or cervix compared to respective negative groups. Cumulative live birth rates per oocyte retrieval in couples where both partners were negative or both were positive did not differ, being 37% (95% CI: 28%–47%) and 44% (95% CI: 19–73), respectively. In conclusion, HPV testing should not be considered a prerequisite for accessing ART treatments. Robust inferences for natural fertility cannot be made using our findings, as the ART setting does not fully reflect natural conditions.

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Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial

Cited by 32 publications

References 32 publications

Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Male and female human papilloma virus infection and assisted reproductive technology outcomes: A comprehensive assessment from prevalence in semen to obstetric outcomes

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