Single particle detection, manipulation and analysis with resonant optical trapping in photonic crystals

Descharmes, Nicolas; Dharanipathy, Ulagalandha Perumal; Diao, Zhaolu; Tonin, Mario; Houdré, R.

doi:10.1039/c3lc50447f

Cited by 51 publications

(41 citation statements)

References 40 publications

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“…11,12 The results in these papers were obtained using a thin PDMS-only microfluidic membrane. The control of the flow inside the microfluidic channel is important for this application, since the measurements have to be in a stable environment.…”

Section: Application To Optical Trapping and Integrated Photonic Crysmentioning

confidence: 99%

“…11,12 Trapping a polystyrene sphere of 500 nm diameter is more efficient with the hybrid microfluidic than with the PDMS-only microfluidic. This is demonstrated when plotting the centroid of the position of the center of emission of a nanoparticle of 500 nm in polystyrene trapped with the same amount of power in both case in Fig.…”

Section: Application To Optical Trapping and Integrated Photonic Crysmentioning

confidence: 99%

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Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

2016

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We demonstrate the fabrication of a hybrid PDMS/glass microfluidic layer that can be placed on top of non-transparent samples and allows high-resolution optical microscopy through it. The layer mimics a glass coverslip to limit optical aberrations and can be applied on the sample without the use of permanent bonding. The bonding strength can withstand to hold up to 7 bars of injected pressure in the channel without leaking or breaking. We show that this process is compatible with multilayer soft lithography for the implementation of flexible valves. The benefits of this application is illustrated by optically trapping subwavelength particles and manipulate them around photonic nano-structures. Among others, we achieve close to diffraction limited imaging through the microfluidic assembly, full control on the flow with no dynamical deformations of the membrane and a 20-fold improvement on the stiffness of the trap at equivalent trapping power.Recent developments in microfluidics show an important trend in the use of polymers and thermoplastics instead of materials such as glass. Polydimethylsiloxane (PDMS) especially holds a privileged role in microfluidics because of several advantages compared to glass and other polymers. First, it is flexible and easy to fabricate by soft lithography. 1 It can be bonded permanently to PDMS or flat surfaces like glass or silicon by oxygen plasma activation. It can also be bonded temporarily by simple conformal contact thanks to van der Waals (VdW) forces, which form a water-tight seal between two flat surfaces. Second, PDMS is biocompatible and rather inexpensive. [2][3][4][5] It is common to use PDMS to fabricate channels for the immersion of nanostructure for sensing applications, such as ring resonators and photonic crystals. [6][7][8][9] Unfortunately, PDMS also has some limitations, 10 in particular when considering high-resolution imaging.In most silicon-based structures, the sample is opaque to visible light. Thus, the imaging has to be done through the microfluidic layer. This also applies to any other opaque samples, like metallic substrates. Mostly two options have been investigated so far. The first option is to use a transparent PDMS microfluidic layer on top of the silicon sample. Another option would be to use a bonded SU8 microfluidic layer. 13 This option is limited to the fabrication of simple, externally driven microfluidic channels and doesn't allow a precise control of the flow within the micro-channels. Precise control of the flow in microfluidic membranes is generally performed with flexible valves. It is necessary when working with small objects in the solution injected in the microchanels.High resolution imaging is generally performed with immersion objectives, which have very strict operational conditions for limiting aberrations. In particular, the refractive index n D and the thickness t of the glass coverslip used have to be as close as possible to the predefined values used to design the objective (typically n D = 1.523 and t = 170 μm). Because of t...

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Section: Application To Optical Trapping and Integrated Photonic Crysmentioning

confidence: 99%

Section: Application To Optical Trapping and Integrated Photonic Crysmentioning

confidence: 99%

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

2016

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“…For instance, Descharmes et al [85,86] reported single particle detection using a PC waveguide cavity with a single large point defect in a hexagonal lattice (Figure 3a). In their experimental setup, it is possible to record large dynamic changes in the power transmitted through the device, while the particle traverses the PC waveguide cavity, as can be observed in Figure 3b.…”

Section: Waveguide Defectmentioning

confidence: 99%

Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing

Aguirre

Long

et al. 2018

Chemosensors

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Abstract:The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.

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“…By employing this mechanism, the PhC cavity enabled the detection of target materials, such as gases, 16 particles, 17 viruses, 18 and biomolecules, 6,19 with an ultrahigh sensitivity according to the structural and surrounding refractive-index changes within a fractional sample volume. Considering its sensitivity and device size (~10 μm), the PhC cavity is promising for the development of microscale optical sensors compared with other technologies, such as surface plasmon resonance, optical waveguides, and ring resonators.…”

Section: Introductionmentioning

confidence: 99%

Polymer-based Photonic Crystal Cavity Sensor for Optical Detection in the Visible Wavelength Region

et al. 2016

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In this study, a polymer-based two-dimensional photonic crystal (PhC) cavity for visible-light-based optical-sensing applications was designed and fabricated for the first time. The PhC cavity configuration was designed to operate at 650 nm, and fabricated with a polymer (resist) on a silicon substrate using electron-beam lithography. For investigating sensing applications based on shifting of condition exhibiting a photonic bandgap (PBG), the polymer monolayer deposition (layer-by-layer method) was monitored as the light-intensity change at the cavity position. Consequently, the monolayer-level detection of polyions was achieved.

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Single particle detection, manipulation and analysis with resonant optical trapping in photonic crystals

Cited by 51 publications

References 40 publications

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing

Polymer-based Photonic Crystal Cavity Sensor for Optical Detection in the Visible Wavelength Region

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