Single Superparamagnetic Bead Detection and Direct Tracing of Bead Position Using Novel Nanocomposite Nano-Hall Sensors

Gabureac, Mihai; Bernau, Laurent; Boero, Giovanni; Utke, Ivo

doi:10.1109/tnano.2013.2266733

Cited by 30 publications

(23 citation statements)

References 37 publications

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“…Frequency-dependent voltage noise mea- damaged [130]. Within the magnetic bead detection and tracing experiments a lateral resolution of 230 nm/ √ Hz was achieved at a field resolution of 300 µT/ √ Hz [132].…”

Section: Gas and Dielectric Sensingmentioning

confidence: 99%

Focused electron beam induced deposition meets materials science

Huth

Porrati

Dobrovolskiy

2018

Microelectronic Engineering

157

172

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simulation-assisted growth of complex three-dimensional nano-architectures is also covered. In the review particular emphasis is laid on conceptual clarity in the description of the different developments, which is reflected in the mostly schematic nature of the presented figures, as well as in the recurring final sub-sections for each of the main topics discussing the respective "challenges and perspectives".

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Section: Gas and Dielectric Sensingmentioning

confidence: 99%

Focused electron beam induced deposition meets materials science

Huth

Porrati

Dobrovolskiy

2018

Microelectronic Engineering

157

172

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“…Gluing a sub-micron particle to the apex of a cantilever tip is a painstaking work that can be substituted by directly growing it 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 nanoscale Hall sensors and was achieved by carefully tuning the composition and dimensions of the Co-based FEBID deposit. An experiment with controlled approximation of a magnetic bead to the Co-based Hall sensor was performed by Gabureac et al (67). By performing the experiment in a SEM chamber, the Hall sensor output is monitored at the same time that the bead is controllably approached to the device.…”

Section: Magnetic Dots For Magnetic Storage and Catalytic Growthmentioning

confidence: 99%

Review of magnetic nanostructures grown by focused electron beam induced deposition (FEBID)

Teresa

Fernández-Pacheco

Córdoba

et al. 2016

J. Phys. D: Appl. Phys.

145

156

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We review the current status of the use of focused electron beam induced deposition (FEBID) for the growth of magnetic nanostructures. This technique relies on the local dissociation of a precursor gas by means of an electron beam. The most promising results have been obtained using the Co 2 (CO) 8 precursor, where the Co content in the grown nanodeposited material can be tailored up to more than 95%. Functional behaviour of these Co nanodeposits has been observed in applications such as arrays of magnetic dots for information storage and catalytic growth, magnetic tips for scanning probe microscopes, nano-Hall sensors for bead detection, nano-actuated magnetomechanical systems and nanowires for domain-wall manipulation. The review also covers interesting results observed in Fe-based and alloyed nanodeposits. Advantages and disadvantages of FEBID for the growth of magnetic nanostructures are discussed in the article as well as possible future directions in this field.

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“…Finally, SPN tags may allow for spatial manipulation of tagged molecules and the removal of unbound tags through the application of magnetic field gradients. 17,18 Several SPN detection schemes have been demonstrated, such as giant magnetoresistive (GMR) sensors, 19,20 magnetic force microscopy (MFM), 21 superconducting quantum interference devices (SQUIDs), 22 micro-Hall sensors 23,24 and magnetic tunnel junctions (MTJs) 25 . Of the methods listed above, detection of single magnetic particles with diameters under 1 µm has only been demonstrated with SQUIDS and MFM.…”

mentioning

confidence: 99%

Room-temperature detection of a single 19 nm super-paramagnetic nanoparticle with an imaging magnetometer

Gould¹,

Barbour²,

Thomas³

et al. 2014

Applied Physics Letters

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We demonstrate room temperature detection of single 20 nm superparamagnetic nanoparticles (SPNs) with a wide-field optical microscope platform suitable for biological integration. The particles are made of magnetite (Fe 3 O 4 ) and are thus non-toxic and biocompatible. Detection is accomplished via optically detected magnetic resonance imaging using nitrogen-vacancy defect centers in diamond, resulting in a DC magnetic field detection limit of 2.3 µT. This marks a large step forward in the detection of SPNs, and we expect that it will allow for the development of magneticfield-based biosensors capable of detecting a single molecular binding event.Keywords: Nitrogen-vacancy center, super-paramagnetic nanoparticles, optically detected magnetic resonance, magnetometry, microscopy.Super-paramagnetic nanoparticles (SPNs) are particles made of ferromagnetic material which, due to their small size, exhibit paramagnetic behavior with magnetic susceptibilities orders of magnitude larger than typical paramagnetic materials. greatly from this capability include highly sensitive assays for cancer, 11,12 HIV, 13 and nonacute-coronary-syndrome cardiac conditions. 14 In particular, digital immuno-assays rely on the detection of single bio-molecules to achieve ultra-high detection sensitivities. 15,16 In this work, we experimentally realize a room temperature platform capable of detecting single 20 nm diameter magnetite SPNs using wide-field optical imaging. NV centers can be viewed as a localized 2-electron system with the energy-level diagram shown in Figure 1(a). The ground state of the system is a spin-triplet, for which the m s = ±1 spin states are degenerate under zero applied magnetic field, and split from the m s = 0 spin state by an energy E ss due to spin-spin interactions. In this work, we perform imaging ODMR measurements on a 200 nm-thick, highdensity sheet of NV centers near the {111} surface of a diamond chip. As depicted in Using this setup, the spatial distribution of the component of the magnetic field normal to the chip surface is imaged. We use a simple difference scheme utilizing only NVs aligned with the applied DC field. Images taken with an RF magnetic field applied to the sensing surface are subtracted from images with no applied RF. The frequency of the RF field is set just below the steepest part of the ODMR curve (f 1 in Figure 1(b)), 5 maintaining a high small-field sensitivity while increasing the signal from the high field in proximity to SPNs.In order to characterize the system's SPN detection capability, magnetite SPNs were deposited on the sensing surface in isolated single particles and small groups. The SPNs were prepared according to a previously reported method. [39][40][41][42] Particle distributions were obtained by drying colloidal suspensions on a lithographically defined pattern on the sensor surface, resulting in a grid pattern with small groups of particles at each grid point. Figures 2(a-b) show scanning electron microscope (SEM) images of a resulting pattern of particle g...

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Single Superparamagnetic Bead Detection and Direct Tracing of Bead Position Using Novel Nanocomposite Nano-Hall Sensors

Cited by 30 publications

References 37 publications

Focused electron beam induced deposition meets materials science

Focused electron beam induced deposition meets materials science

Review of magnetic nanostructures grown by focused electron beam induced deposition (FEBID)

Room-temperature detection of a single 19 nm super-paramagnetic nanoparticle with an imaging magnetometer

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