We report the realization of an array of four tunnel coupled quantum dots in the single electron regime, which is the first required step toward a scalable solid state spin qubit architecture. We achieve an efficient tunability of the system but also find out that the conditions to realize spin blockade readout are not as straightforwardly obtained as for double and triple quantum dot circuits. We use a simple capacitive model of the series quadruple quantum dots circuit to investigate its complex charge state diagrams and are able to find the most suitable configurations for future Pauli spin blockade measurements. We then experimentally realize the corresponding charge states with a good agreement to our model. Quantum dot (QD) circuits have demonstrated to be particularly good systems for studying electronic transport and for implementing solid state qubits. They notably offer the possibility to control the spin of confined single electrons to realize spin qubits 1,2 . These are especially attracting for quantum information processing because of their robustness to decoherence 3,4 which should allow to implement a full electron-spin based quantum computation scheme 5 . Among the various materials in which such QDs based spin qubits have been demonstrated, semiconductor heterostructures are considered candidates of choice because of the high tunability and readout techniques they offer. Lately, several experiments demonstrated the manipulation of two spin-1/2 qubits implemented in double QD (DQD) circuits as well as the realization of universal quantum one-and twoqubits gate operations 6-8 . An additional key feature of these semiconductor QD circuits is their potential for scalability 9 .Realization of a scalable architecture of semiconductor spin qubits is one of the remaining challenge that has to be overcome for implementing more complex algorithms. Steps toward this direction have been taken by experimentally realizing triple QD (TQD) circuits 10,11 or quadruple QD (QQD) circuits formed by two capacitively coupled DQDs 12 . In these systems however, the number of implemented qubits is still limited to one or two. A square-like configuration of tunnel coupled QQD device has also been demonstrated 13 , in the single electron a) matthieu.delbecq@riken.jp regime already. This particular configuration is however a priori less suitable for scalability than the series configuration discussed in this letter. Very recently, a tunnel coupled series-QQD device has been realized and studied in the multiple electrons regime 14 , showing a good control of the tunnel couplings and gate potentials to form the dots. In this letter, we show that by following the same architecture, we can reach the single electron regime for each QD, which is a mandatory condition for making four spin qubits. We furthermore demonstrate an efficient tunability of the system in this regime, with which we are able to realize the proper charge state configurations for spin blockade readout.The scanning electron microscopy image of the device st...