Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application

Choi, Kyu-Hong; Wang, Kang Kyun; Oh, Sojin; Im, Ji Eun; Kim, Bong Jin; Park, Jong Chul; Choi, Donghoon; Kim, Hwan Kyu; Kim, Yong Rok

doi:10.1016/j.surfcoat.2010.04.033

Cited by 11 publications

(9 citation statements)

References 28 publications

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“…However, in the plot for the HP-coated Ti substrate, a gradual decrease in OD is observed with time under the light condition. This result indicates that the HP-coated Ti substrate generated a small amount of the singlet oxygen compared with the previous report [ 22 ]. However, this substrate has a very high degree of biocompatibility as it is composed of three nontoxic materials without any other additives.…”

Section: Resultssupporting

confidence: 65%

“…This excited state may then undergo intersystem crossing to the slightly lower energy but longer-lived triplet state. This triplet state of the PS can either interact with oxygen to produce singlet oxygen (Type II reaction) or directly react with the molecules near the immediate vicinity (Type I reaction) [ 22 ]. Therefore, PDT is a promising alternative to treat diseases ranging from cancer to antibiotic-resistant infections because it is based on the utilization of a type of compound that inhibits or kills microorganisms using only the effect of light [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study, we demonstrated the preparation of a singlet-oxygen-generating nanolayer coating on a biocompatible NiTi alloy using indirect coating process [ 22 ]. In this study, we successfully fabricated hematoporphyrin- (HP-) coated Ti substrates using direct conjugation process.…”

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Photofunctional Nanolayer Coatings on Titanium Substrates

Choi

Kim

Kang

et al. 2016

BioMed Research International

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We developed a two-step chemical bonding process using photosensitizer molecules to fabricate photofunctional nanolayer coatings on hematoporphyrin- (HP-) coated Ti substrates. In the first step, 3-aminopropyltriethoxysilane was covalently functionalized onto the surface of the Ti substrates to provide heterogeneous sites for immobilizing the HP molecules. Then, HP molecules with carboxyl groups were chemically attached to the amine-terminated nanolayer coatings via a carbodiimide coupling reaction. The microstructure and elemental and phase composition of the HP-coated Ti substrates were investigated using field-emission scanning electron microscopy and energy-dispersive X-ray spectrometry. The photophysical properties of the photofunctional nanolayer coatings were confirmed using reflectance ultraviolet-visible absorption and emission spectrophotometry. The singlet oxygen generation efficiency of the photofunctional nanolayer coatings was determined using the decomposition reaction of 1,3-diphenylisobenzofuran. The HP-coated Ti substrates exhibited good biocompatibility without any cytotoxicity, and these nanolayer coatings generated singlet oxygen, which can kill microorganisms using only visible light.

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Section: Resultssupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Photofunctional Nanolayer Coatings on Titanium Substrates

Choi

Kim

Kang

et al. 2016

BioMed Research International

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“…Figure 2(b) shows ATR-IR spectra of the surface modified NAM with APTES, PtCP, and the PtCP bounded surface modified NAM (PNAM). The peaks of PtCP in the spectrum are assigned to be the carbonyl stretching mode of the carboxyl group at 1690 cm −1 , the stretching vibration mode of the conjugated C=C bond at 1605 cm −1 , and the C-H stretching vibration mode at 1360, 1315 cm −1 from the references [18][19][20]. The spectrum of the surface modified NAM shows the stretching vibration mode of −NH 2 group at 1639 cm −1 [21,22].…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Photofunctional Nanoporous Membrane and Its Photoinactivation Effect of Vesicular Stomatitis Virus

Wang

Kim

et al. 2011

Journal of Nanomaterials

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Fabrication and photophysical study of photofunctional nanoporous alumina membrane (PNAM) were performed, and its application of photodynamic antimicrobial chemotherapy (PACT) was investigated. Nanoporous alumina membrane (NAM) was fabricated by two-step aluminium anodic oxidation process. Surface of the fabricated NAM was modified with organo-silane agent to induce covalent bonding between NAM and a photosensitizer (PtCP: [5,10,15-triphenyl-20-(4-methoxycarbonylphenyl)-porphyrin] platinum). PtCP was covalently bonded to the surface of the modified NAM by nucleophilic acyl substitution reaction process. The morphology and the photophysical properties of the fabricated PNAM were confirmed with field emission scanning electron microscope (FE-SEM), steady-state spectroscopies, and nanosecond laser-induced time-resolved spectroscopy. For the efficacy study of PNAM in PACT, an enveloped animal virus, vesicular stomatitis virus (VSV), was utilized as a target organism. Antiviral effect of the PNAM-PACT was measured by the extent of suppression of plaque-forming units (PFU) after the light irradiation. In the cultures inoculated with PACT-treated VSV, the suppression of PFU was prominent, which demonstrates that PNAM is a potential bio clean-up tool.

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“…It is considered that photodamage to cell is predominantly caused by singlet oxygen via type II reactions [22,23], but it is also proved that photosensitized action is caused by both type I and type II pathways [24,25]. Ergaieg et al [24] have reported that type I reactions had a significant role in inactivation of Gram-negative bacteria whereas the photoinactivation rate of Gram-positive bacteria was unchanged even in the absence of superoxide anion.…”

Section: Visible Light Photodisinfectionmentioning

confidence: 99%

Phototreatment of Water by Organic Photosensitizers and Comparison with Inorganic Semiconductors

Thandu

Comuzzi

Goi

2015

International Journal of Photoenergy

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Phototreatment of water is drawing the attention of many as a promising alternative to replace methods like chlorination, ozonization, and other oxidation processes, used in current disinfection methods limiting harmful side-products and by-products that can cause damage to the fauna and flora. Porphyrins, phthalocyanines, and other related organic dyes are well known for their use in photodynamic therapy (PDT). These photosensitizers cause cell death by generating reactive oxygen species (ROS) especially singlet oxygen in the presence of light. Such molecules are also being explored for photodynamically treating microbial infections, killing of unwanted pathogens in the environment, and oxidation of chemical pollutants. The process of photosensitisation (phototreatment) can be applied for obtaining clean, microbe-free water, thus exploiting the versatile properties of photosensitizers. This review collects the various attempts carried out for phototreatment of water using organic photosensitizers. For comparison, some reports of semiconductors (especially TiO2) used in photocatalytic treatment of water are also mentioned.

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Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application

Cited by 11 publications

References 28 publications

Facile Synthesis of Photofunctional Nanolayer Coatings on Titanium Substrates

Facile Synthesis of Photofunctional Nanolayer Coatings on Titanium Substrates

Fabrication of Photofunctional Nanoporous Membrane and Its Photoinactivation Effect of Vesicular Stomatitis Virus

Phototreatment of Water by Organic Photosensitizers and Comparison with Inorganic Semiconductors

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