Singlevs multidrung therapy in enteric fever

Balasubramanian, Sundaram; Rajeswari,; Sailakshmi, None; Shivbalan, So

doi:10.1007/bf02758273

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasonography and the areaspecific (liver) hematocrit were both sensitive for detecting and excluding plasma leakage for dengue detection. 18 A study conducted by Parmar et al showed significant ultrasound changes in Gall gallbladder wall thicknessening (GBWT) in admitted dengue patients, which is concurrent with the results of this study. 19 Ultrasonographic findings compete to be one of the most reliable methods of diagnosis and severity of dengue fever, along with serological measures in the patients.…”

Section: Discussionsupporting

confidence: 89%

Clinical Significance of Ultrasonographic Findings in Dengue Patients; The Comparison of 2019 and 2022 Out Breaks

Baseer,

Shan,

Rehman

et al. 2023

PAFMJ

View full text Add to dashboard Cite

Objective: To signify the ultrasonographic findings as an adjunct to serological diagnosis of dengue fever and to correlate ultrasound findings of dengue patients from the disease outbreak in 2019 and 2022 Pakistan with serological parameters such as platelet count, WBC and hematocrit. Study Design: Prospective longitudinal study. Place and Duration of Study: Radiology Department, Federal Government Polyclinic (PGMI), Islamabad, Pakistan from Jan2019 to Dec 2022. Methodology: All patients referred to the Radiology Department for an Ultrasound Abdomen, who were admitted to the Hospital Isolation Unit and were found to have anti-dengue serology, were included in the data. Ultrasonographic findings of dengue patients from the disease outbreak in 2019 and 2022 along with serological parameters such as platelet count, WBC and Hematocrit were assessed. Results: Out of 343 diagnosed dengue fever patients from the 2019 and 2022 outbreaks Pakistan, the majority (n=176; 51.3%) patients had thickening of the gall bladder wall finding, followed by hepatomegaly (n=100; 29.2%), ascites (n=94;27.4%), pleural effusion (n=84; 24.5%), splenomegaly (n=47; 13.7%) and perinephric fluid (n=8;2.3%). Thickness of the gallbladder (n=90; 68.2%) wall was most common in cases with platelet counts <40,000. There was a statistically significant difference found with reduced platelet count and gall bladder wall thickening (p-value < 0.001), pleural effusion (p-value=0.008) and ascites (p-value < 0.001). In 2019, Dengue fever was more severe than in 2022 in patients. Conclusion: The ultrasonographic findings and their co-relation with serological parameters identify USG as a competitive diagnostic procedure for dengue fever

show abstract

Section: Discussionsupporting

confidence: 89%

Clinical Significance of Ultrasonographic Findings in Dengue Patients; The Comparison of 2019 and 2022 Out Breaks

Baseer,

Shan,

Rehman

et al. 2023

PAFMJ

View full text Add to dashboard Cite

show abstract

“…However, the significance of this finding should be confirmed with large clinical trials for its safety and efficacy. In contrast, a comparative Indian study of 62 typhoid fever patients failed to reveal a significant difference in time to defervescence between the single drug (fluoroquinolone or third-generation cephalosporin) and combination drug group (fluoroquinolone with third-generation cephalosporin) [ 79 ].…”

Section: Typhoid Fever Therapy: Challenges In Clinical Practicementioning

confidence: 99%

Typhoid Fever: Issues in Laboratory Detection, Treatment Options & Concerns in Management in Developing Countries

et al. 2018

View full text Add to dashboard Cite

Multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi (resistant to ampicillin, chloramphenicol and cotrimoxazole), was significantly reduced with the increased usage of fluoroquinolones and azithromycin. This has led to declining multidrug resistance rates in India with increasing ciprofloxacin nonsusceptibility rates and clinical failures due to azithromycin. However, for the available agents such as ceftriaxone, azithromycin and fluoroquinolones, the dose and duration for treatment is undefined. The ongoing clinical trials for typhoid management are expected to recommend the defined dose and duration for better clinical outcome. We made an attempt to summarize the issues in laboratory detection, treatment options and responses, and the concerns in clinical practice seen in the developing countries.

show abstract

“…There are difficulties in following the WHO criteria in recognizing plasma leakage for diagnosis of DHF. Hemoconcentration (>20%) is usually diagnosed retrospectively and also requires repeated sampling, while hypoproteinemia can be an infrequent finding [2]. Radiographic investigations even though detect effusions, it often requires multiple films to demonstrate the ongoing collections in the pleural cavity which increases the risk of radiation exposure, but ultrasound can detect even smaller amount of pleural effusion and ascites in children with transient plasma leakage and it is highly sensitive.…”

mentioning

confidence: 99%

Role of ultrasound in early prediction of severity of dengue infection

Malleshappa

Srinivasa

2022

Indian J Child Health

View full text Add to dashboard Cite

Background: Dengue has become a major international health problem in recent years. As per the World Health Organization, dengue has shown a 30-fold increase globally over the past five decades, and approximately, 50-100 million new infections are estimated to occur annually in more than 100 endemic countries. Objective: To evaluate the sonographic findings in children with dengue fever (DF) and to determine its role in predicting the severity of the disease. Methods: One hundred and twenty dengue serology-positive cases in the age group of 2 months to 18 years were studied. These children were divided into two groups - mild (dengue hemorrhagic fever [DHF] I-II without shock) and severe dengue (DHF III-IV with shock). Sonographic variables of these cases were studied and compared by applying appropriate statistical analysis. Results: Out of 120 cases, gallbladder wall thickness (83.3%) and pericholecystic edema (81.6%) were the most common sonographical findings. When sonographic variables of mild and severe groups compared, significant statistical difference was noted in variables such as ascites, pleural effusion, and perinephric edema with p=0.0015, p=0.0058, p<0.000, respectively. Conclusion: Ultrasound can be used as an adjunct modality in patients with suspected DF to detect early signs suggestive of the disease and also useful tool to predict severity of the disease.

show abstract

Singlevs multidrung therapy in enteric fever

Cited by 5 publications

References 0 publications

Clinical Significance of Ultrasonographic Findings in Dengue Patients; The Comparison of 2019 and 2022 Out Breaks

Clinical Significance of Ultrasonographic Findings in Dengue Patients; The Comparison of 2019 and 2022 Out Breaks

Typhoid Fever: Issues in Laboratory Detection, Treatment Options & Concerns in Management in Developing Countries

Role of ultrasound in early prediction of severity of dengue infection

Contact Info

Product

Resources

About