Liquid crystals generally support orientational singularities of the director field known as topological defects. These latter modifiy transport properties in their vicinity as if the geometry was non-Euclidean. We present a state of the art of the differential geometry of nematic liquid crystals, with a special emphasis on linear defects. We then discuss unexpected but deep connections with cosmology and high-energy-physics, and conclude with a review on defect engineering for transport phenomena.