2015
DOI: 10.1016/j.molimm.2015.01.014
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Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues

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Cited by 57 publications
(44 citation statements)
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“…SIN increased the frequency of Treg cells and decreased the frequency of Th17 cells, which was consistent with our previous findings in rat CIA. 2 Notably, the reciprocal regulatory effect of SIN on Th17 and Treg cells was almost completely reversed by RES treatment, indicating that SIN might recover Th17/Treg balance in an AhR-dependent manner. (Figure 5h).…”
Section: Sin Acted As An Ahr Ligandmentioning
confidence: 96%
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“…SIN increased the frequency of Treg cells and decreased the frequency of Th17 cells, which was consistent with our previous findings in rat CIA. 2 Notably, the reciprocal regulatory effect of SIN on Th17 and Treg cells was almost completely reversed by RES treatment, indicating that SIN might recover Th17/Treg balance in an AhR-dependent manner. (Figure 5h).…”
Section: Sin Acted As An Ahr Ligandmentioning
confidence: 96%
“…24 Recently, we investigated the immunomodulatory effect of SIN in rat CIA, an animal model of RA whose development is dependent on the participation of Th17 and Treg cells. 2 Treatment of CII-immunized rats with SIN resulted in a dose-dependent inhibition of arthritis severity through the recirculation of lymphocytes from the gut to the inflamed joint. 2 The present study was designed to investigate how SIN affects the differentiation and function of these cells.…”
Section: Sin Acted As An Ahr Ligandmentioning
confidence: 99%
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“…Its intraperitoneal (i.p.) administration shows to be effective for the treatment of RA by suppressing IL‐6, MMP‐2 and MMP‐9 in arthritic animal model …”
Section: Herbal Pharmacotherapy In Rheumatoid Arthritismentioning
confidence: 99%