Background Transsphenoidal surgery for sellar lesions may affect patency
and function of the nasal airways, smell and sinonasal quality of life. Below is
our report on otorhinolaryngological data garnered from patients undergoing
endonasal transsphenoidal pituitary microsurgery.
Methods In a prospective study, 68 patients scheduled for transsphenoidal
operations (32 female, 36 male, age 17–72 years) underwent
otorhinolaryngological evaluation of their nasal morphology, a standardized
smell test (sniffin’ sticks) and rhinomanometry to analyse nasal
breathing function preoperatively, 3–5 days postoperatively (without
rhinomanometry), after 3–4 months and after 9 months.
Results Immediately after surgery, a reduction in smell sensation was
detected in almost all patients. Within 3 months, this impairment resolved in
all cases except one. In 2 patients (3%) with preoperative anosmia,
improvement of smell function to>6 out of 12 sniffin’ sticks was
observed. At final visit no patient was noted to have new anosmia. Within 3
months, the results of the rhinomanometry revealed that all patients except one,
regained their preoperative nasal breathing function. In 6 patients
(8.8%) an improvement in their nose breathing abilities compared to the
preoperative state was found. Three patients (4.4%) underwent a LASER
transection of mucosal synechiae. In one case with persistent nasal obstruction
(1.5%), secondary septoplasty had to be performed. There was no case in
which perforation of the nasal septum, nasal tip deflection, or saddle nose
deformity was observed.
Conclusion Microsurgical resection of pituitary tumors via the endonasal
transsphenoidal approach poses an acceptable risk with regards to sinonasal
complications. The incidence of secondary rhinosurgical interventions is low.
Standardized comparative studies between endoscopic and microsurgical
transsphenoidal operations should be undertaken.