Sinonasal hybrid tumour involving the anterior skull base

Abstract

Objective: We report a rare case of sinonasal hybrid tumour within an inverted papilloma.Method: The patient's case history and course of management are presented. The relevant medical literature are reviewed and discussed.Results: A 60-year-old man presented with unilateral nasal obstruction associated with anosmia. An ENT examination revealed a unilateral, left nasal mass. A provisional diagnosis of inverted papilloma was made. The patient underwent a transnasal endoscopic excision of the tumour, which was unfortunately complicated by a cerebrospinal fluid leak. Further treatment of this patient is described. We highlight the features of associated malignancy in inverted papilloma, and the importance of thorough histopathological examination of tissue specimens.Conclusion: Treatment of inverted papilloma with limited involvement of the skull base can be successfully achieved by endoscopic excision. A high index of clinical suspicion, together with meticulous histopathological examination, will enable diagnosis of associated malignancy. This will ensure that appropriate adjuvant treatment is given, resulting in a good clinical outcome.

Skull Base Inverted Papilloma: A Comprehensive Review

“…The extent of disease primarily determines the choice of surgical approach, with previous treatment, individual patient factors, and surgical expertise are secondary determinants [317, 365–369]. Limited involvement of the skull base can be successfully achieved by endoscopic excision [370]. Endoscopic resection of IP was associated with shorter hospital stay [371, 372], equivalent estimated blood loss [372], equivalent to shorter operative time [339, 371, 372], and lesser morbidity [339, 371].…”

Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States

“…Variant sinonasal verrucous carcinoma (SNVC) similarly has been described in prior case reports . An interesting yet unclear association of SNVC with inverting papillomas has been reported . Given its rarity, evidence regarding the epidemiology and factors affecting survival outcomes are limited to various case reports.…”