Sintering effects of mullite-doping on mechanical properties of bovine hydroxyapatite

Yetmez, Mehmet; Erkmen, Ziya Engin; Kalkandelen, Cevriye; Ficai, Anton; Oktar, Faik N.

doi:10.1016/j.msec.2017.03.290

Cited by 37 publications

(21 citation statements)

References 17 publications

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“…Thus, these extraction methods can be used to extract HA and SF from industrial waste. Furthermore, the pathogens present in bovine bone are removed at temperature above 800 °C [ 87 , 88 ]. Therefore, locally extracted HA has a low possibility of transmitting diseases.…”

Section: Discussionmentioning

confidence: 99%

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

et al. 2020

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The full-thickness articular cartilage defect (FTAC) is an abnormally severe grade of articular cartilage (AC) injury. An osteochondral autograft transfer (OAT) is the recommended treatment, but the increasing morbidity rate from osteochondral plug harvesting is a limitation. Thus, the 3D-printed bilayer’s bioactive-biomaterials scaffold is of major interest. Polylactic acid (PLA) and polycaprolactone (PCL) were blended with hydroxyapatite (HA) for the 3D-printed bone layer of the bilayer’s bioactive-biomaterials scaffold (B-BBBS). Meanwhile, the blended PLA/PCL filament was 3D printed and combined with a chitosan (CS)/silk firoin (SF) using a lyophilization technique to fabricate the AC layer of the bilayer’s bioactive-biomaterials scaffold (AC-BBBS). Material characterization and mechanical and biological tests were performed. The fabrication process consists of combining the 3D-printed structure (AC-BBBS and B-BBBS) and a lyophilized porous AC-BBBS. The morphology and printing abilities were investigated, and biological tests were performed. Finite element analysis (FEA) was performed to predict the maximum load that the bilayer’s bioactive-biomaterials scaffold (BBBS) could carry. The presence of HA and CS/SF in the PLA/PCL structure increased cell proliferation. The FEA predicted the load carrying capacity to be up to 663.2 N. All tests indicated that it is possible for BBBS to be used in tissue engineering for AC and bone regeneration in FTAC treatment.

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Section: Discussionmentioning

confidence: 99%

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

et al. 2020

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“…Figure 7 shows that the addition of 10 mass% forsterite led to a reduction in the particle size. Such a reduction in the particle size caused a reduction in the crack free path, which in turn improved the strength [2,25]. An increase in the forsterite content to 30 mass% led to a decrease in the mechanical properties.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Calcium phosphate ceramics, which exist in different phases, are the most common materials to be used due to their bioactivity and degradability [1]. Hydroxyapatite (HA) is a member of the calcium phosphate family and has extraordinary properties that make this material compatible with bone tissues and enhance bone growth [2][3][4][5]. HA has been used for many clinical applications, such as bone repair, bone growth, and coating of metallic implants [6].…”

Section: Introductionmentioning

confidence: 99%

“…Hannora et al [8] prepared HA/titania composites by a high-energy ball milling technique and achieved a high crushing strength of more than 200 MPa in comparison to 50 MPa for pure hydroxyapatite. The addition of 15 wt% zirconia-toughened alumina (ZTA) and 10 wt% mullite to hydroxyapatite both improved the bending strength by ≈240% [9] and improved the compressive strength and microhardness [2].…”

Section: Introductionmentioning

confidence: 99%

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Forsterite/nano-biogenic hydroxyapatite composites for biomedical applications

Naga

Hassan

Awaad

et al. 2020

Journal of Asian Ceramic Societies

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Recently, silicate materials have received attention as materials with promising applications in the bioceramics field. A recent study aimed to investigate the effect of forsterite (Mg 2 SiO 4) addition to biogenic hydroxyapatite, Ca 10 (PO 4) 6 (OH) 2 , on the phase formation, physical and mechanical properties, and biocompatibility of the produced composites. Different proportions of forsterite, 10 to 40 mass%, were added to hydroxyapatite obtained from fish bones to prepare the target composites. Various techniques, such as X-ray diffraction analysis (XRD), scanning electronic microscope (SEM), transmission electronic microscope (TEM), mechanical strength measurements and in vitro studies, were carried out to evaluate the composite properties. The results indicate that the addition of 20 to 40 mass% forsterite led to the transformation of forsterite into protoenstatite and the formation of Mg-rich whitlockite at the expense of hydroxyapatite. It is concluded that 20 mass% forsterite is the optimum addition amount to enhance the physical and mechanical properties of the produced composites. The cell culture tests and in vitro studies agree with the abovementioned results.

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“…The mullite content of samples was increased from 5 wt % to 10 wt % at 1350 °C, and the porosity increased from 6.8% to 21.3%. Yetmez et al [ 19 ] considered sintering effects on the properties of bovine-derived HA doped with powder mullite. With sintering increasing temperature from 1000 to 1300 °C, the Vickers hardness, density, and compressive strength reached 1369 HV, 2.62 g/cm 3 , and 101 MPa, respectively.…”

Section: Introductionmentioning

confidence: 99%

Sintering Behavior and Mechanical Properties of Mullite Fibers/Hydroxyapatite Ceramic

et al. 2018

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The effect of fiber content and sintering temperature on sintering behavior and mechanical properties of mullite fibers/hydroxyapatite composites was studied. The composites were fabricated by hydrothermal synthesis and pressureless sintering. The amount of fibers was varied from 5 wt % to 15 wt % through hydrothermal synthesis, mullite fibers and hydroxyapatite composite powders were subsequently sintered at temperatures of 1150, 1250, and 1350 °C. The composites presented a more perturbed structure by increasing fiber content. Moreover, the composites experienced pore coalescence and exhibited a dense microstructure at elevated temperature. X-ray diffraction indicated that the composites underwent various chemical reactions and generated silicate glasses. The generation of silicate glasses increased the driving force of particle rearrangement and decreased the number of pores, which promoted densification of the composites. Densification typically leads to increased hardness and bending strength. The study proposes a densification mechanism and opens new insights into the sintering properties of these materials.

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Sintering effects of mullite-doping on mechanical properties of bovine hydroxyapatite

Cited by 37 publications

References 17 publications

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

Forsterite/nano-biogenic hydroxyapatite composites for biomedical applications

Sintering Behavior and Mechanical Properties of Mullite Fibers/Hydroxyapatite Ceramic

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