Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

Siddiq, Hadi Barru Hakam Fajar; Rashati, Dewi; Nurmalasari, Dewi Riskha

doi:10.24123/mpi.v2i2.1319

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Amoxicillin is a broad-spectrum antibiotic, used for treatments such as infections of the airways, bile ducts, and arteries, gonorrhea, gastroenteritis, meningitis, and infections due to Salmonella sp, such as typhoid fever. The mechanism of action of amoxicillin is to inhibit bacterial cell wall synthesis by binding one or more of the penicillin-protein bonds so that it causes inhibition of cell wall biosynthesis so that bacteria break (Ariani et al 2019;Siddiq, 2019). The active rosella (Hibiscus sabdariffa L.) crown infusion is said to be antibacterial due to the chemical components contained in the rosella flower crown (Hibiscus sabdariffa L.) plant.…”

Section: Minimun Inhibitory Concentrationmentioning

confidence: 99%

Phytochemical screening of bunga rosella (Hibiscus sabdariffa L) and antimicrobial activity test

Purba¹,

Simanjuntak²,

Situmorang³

2020

JPKim

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The purpose of this study was to determine the antimicrobial activity of rosella infusa (Hibiscus sabdariffa L.). Antimicrobial inhibition test using infusa of rosella (Hibiscus sabdariffa L.) against Staphylococcus aureus and Escherichia coli bacteria at a concentration of infusa 100%; 75%; and 50%. The concentration has highest potential antibacterial of infusa for Staphylococcus aureus is 100% witch has diameter of 13.6 mm and for Escherichia coli bacteria is 100%, its show that diameter of zone inhibitory zone is 13.3 mm. The Results of phytochemical screening show that infusa of rosella (Hibiscus sabdariffa L.) contains flavonoids, saponins, and tannins. Based on the data above show that the infusa of rosella flower has high antibacterial potential.

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Section: Minimun Inhibitory Concentrationmentioning

confidence: 99%

Phytochemical screening of bunga rosella (Hibiscus sabdariffa L) and antimicrobial activity test

Purba¹,

Simanjuntak²,

Situmorang³

2020

JPKim

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“…Senyawa ini juga mempunyai aktivitas terhadap bakteri Gram positif maupun Gram negatif lainnya (Soekardjo et al, 2000), sehingga senyawa ini dapat dijadikan sebagai senyawa induk untuk dikembangkan lebih lanjut dalam usaha mendapatkan senyawa baru dengan aktivitas antibakteri yang lebih tinggi. Sintesis senyawa turunan lain dari amoksisilin juga telah dilakukan oleh Siddiq et al (2018) yaitu dengan mereaksikan senyawa amoksisilin dengan 4t-butilbenzoil klorida.…”

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SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA TURUNAN AMOKSISILIN TERHADAP Escherichia coli

Siddiq¹,

Azizah²,

Hidayah³

et al. 2022

J. Ilm. Farm. Akademi Farmasi jember

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Amoxicillin derivate compounds from the reaction of amoxicillin with p-aminophenol are synthesized compounds by reacting amoxicillin and p-aminophenol. . Escherichia coli is a flora normal bacteria that can causing infectious diseases. This research aimed to determine the antibiotic activity of amoxicillin derivat compound (amoxicillin with p-aminophenol) on the growth of E. coli. This research was conducted using the disc diffusion method. amoxicillin derivat compound (amoxicillin with p-aminophenol) were characterized by organoleptic test, melting point determination, pH test determination, Rf value, and maximum wavelength. The results of the organoleptic test showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction is crystal powder, dark brown and bit bitter. Melting point of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 160ºC. pH test of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 6,5. Rf value of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 0,79. The results of UV wavelength scanning showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction at 295 nm. Antibiotic activity showed by the clear zone form around the paper disk. The results showed that E. coli was resistant to pure amoxicillin. Amoxicillin derivat compound (amoxicillin with p-aminophenol) with concentrations of 100% and 12,5% have the largest inhibitory zones (6,33 mm) compared with concentrations of 50% and 25%, 5,33 and 6,00 mm respectively. Based on these results it can be concluded that derivat compound of amoxicillin (amoxicillin with p-aminophenol) has antibiotic activity against the growth of E. coli that has been resistant to pure amoxicillin.

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Synthesis and Antibacterial Activity Test of Dibutyl Tin (IV) N-Ethylbenzyl Dithiocarbamate Compound Against Salmonella Thy.Atcc.14028 and Propionibacterium acnes Bacteria

Sanuddin,

Andriani,

Angraini

2024

J. Kim. Sains Apl.

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The complex compound dithiocarbamate exhibits various biological activities, including anticancer, antibacterial, antifungal, and antioxidant properties. Dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was synthesized to overview its structure and evaluate its antibacterial activity against Salmonella typhimurium ATCC 14028 and Propionibacterium acnes. This compound was synthesized via an in situ method by adding dibutyl tin (IV) dichloride, N-ethylbenzylamine, and carbon disulfide, forming a precipitate, which was then dried to yield a white powder. This powder can also be crystallized. The compound was characterized using FTIR, 1H NMR, and 13C NMR spectroscopy, along with antibacterial activity testing using the disc diffusion method. The FTIR analysis revealed characteristic absorption bands at 1111.00 cm-1 (C-N), 731.02 cm-1 (C-S), 2954.95 cm-1 (C-H), 1602.85 cm-1 (C=C), 360.69 cm-1 (Sn-S), and 567.07 cm-1 (Sn-C). The 1H NMR spectrum showed chemical shifts at 0-3.8570 ppm (δ CH3), 5.0032-5.1472 ppm (δ N-CH2), and 7.2780-7.3607 ppm (δ C6H5). The 13C NMR spectrum displayed signals at 0-34.5610 ppm (δ CH3), 48.6398-56.9247 ppm (δ N-CH2), 127.6651-135.7665 ppm (δ C6H5), and 201.7568 ppm (δ CS2). The antibacterial activity of dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was assessed, revealing inhibition zones against Salmonella typhi of 6.78 mm (100 ppm), 7.36 mm (120 ppm), and 7.76 mm (140 ppm), categorizing the activity as moderate. Against Propionibacterium acnes, inhibition zones were 1.8 mm (100 ppm), 1.88 mm (120 ppm), and 2.13 mm (140 ppm), categorizing the activity as weak. Based on these findings, it can be concluded that dibutyl tin (IV) N-ethyl benzyl dithiocarbamate can be synthesized to form an octahedral structure and exhibits antibacterial activity. However, it is not yet suitable for use as a new antibiotic.

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Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

Cited by 4 publications

References 7 publications

Phytochemical screening of bunga rosella (Hibiscus sabdariffa L) and antimicrobial activity test

Phytochemical screening of bunga rosella (Hibiscus sabdariffa L) and antimicrobial activity test

SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA TURUNAN AMOKSISILIN TERHADAP Escherichia coli

Synthesis and Antibacterial Activity Test of Dibutyl Tin (IV) N-Ethylbenzyl Dithiocarbamate Compound Against Salmonella Thy.Atcc.14028 and Propionibacterium acnes Bacteria

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