Sinus floor augmentation with β‐tricalciumphosphate (β‐TCP): does platelet‐rich plasma promote its osseous integration and degradation?

Abstract

When dental implants are to be inserted, sinus floor augmentation is an effective treatment procedure to improve bone height in the posterior maxilla. In addition to autogenous bone material, allogenic materials, e.g. beta-tricalciumphosphate (beta-TCP), have been used successfully. The purpose of this study was to investigate whether the combination of beta-TCP with platelet-rich plasma (PRP) enhances bony regeneration and resorption of the tricalciumphosphate material. In a randomized prospective trial, 45 sinus floor elevations were performed in 39 patients. In 22 sites, PRP was added to the beta-TCP granules, while in 23 sites beta-TCP without PRP was used. Six months later, bone specimens were harvested from the augmented region during the implant insertion procedure. The formation of new bone was about 8-10% higher when PRP was applied. A faster degradation of the ceramic bone substitute was not observed. In conclusion, when PRP was added to beta-TCP, bone regeneration was supported to a small extent. However, the resorption of beta-TCP was not accelerated and foreign-body giant cells and soft tissue surrounding the beta-TCP granules were present.

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

“…Fürst et al 32 (bovine bone) and Klongnoi et al 33 (autogenous bone, bioactive glass) do not demonstrate positive results with PRP. However, Wiltfang et al 18 (autogenous bone) show positive results with the use of the PRP.…”

“…In humans, many authors demonstrate positive results with the use of PRP in situations of tissue repair 2,3,17,[18][19][20][21][22] , while others, however, do not observe benefits 9,23 .…”

“…Fürst et al 32 , Wiltfang et al 18 and Klongnoi et al 33 use minipigs as experimental animal. Fürst et al 32 (bovine bone) and Klongnoi et al 33 (autogenous bone, bioactive glass) do not demonstrate positive results with PRP.…”

Using fractal dimension to evaluate alveolar bone defects treated with various bone substitute materials

“…The fast changes during six to eight months, described by many authors, (complete resorption when implanted in humans) [25,61] maybe though proved in our study. Tamimi indicates that the new bone at the site of biomaterial implantation differs from the intact one after 24 months and it still differs at the maximum recorded time of 36 months after the surgery [62].…”

Influence of Platelets Rich Plasma on Repair of Superficial Digital Flexor Tendon Rupture in Donkeys (An Experimental Study)

“…The exact mechanisms of PRP on the inflammatory response after acute tendon injury is not excluded yet, but many studies postulated that the therapeutic effects of PRP in tendon repair could be attributed to the high content of PRP in many growth factors and anti-inflammatory cytokines such as PDGF, IGF-I, bFGF, VEGF and HGF, EGF, DAF, platelet factor 4, ECGF, FGF and stromal cell derived factor 1α [6,[11][12][13]. These factors had major effects on tendon repair via promoting angiogenesis, fibroblast proliferation, leukocyte chemotaxis, collagen deposition, and remodeling [29][30][31].…”