Sinus Inflammation Associated with Contralateral Inverted Papilloma

Orlandi, Richard R.; Rubin, Adam D.; Terrell, Jeffrey E.; Anzai, Yoshimi; Bugdaj, Melissa; Lanza, Donald C.

doi:10.1177/194589240201600204

Cited by 38 publications

(60 citation statements)

References 9 publications

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“…Therefore, other risk factors, such as allergic rhinitis, smoking and occupation, which may predispose to sinonasal papilloma, were ignored. Chronic sinusitis is reported to occur in either side and inflammation is considered to be one of the causes of the sinonasal papilloma (Orlandi et al 2002;Orlandi 2010). However, this study showed a different tendency.…”

Section: Discussionmentioning

confidence: 99%

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Association between Septal Deviation and Sinonasal Papilloma

Nomura

Ogawa

Sugawara

et al. 2013

Tohoku J. Exp. Med.

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Sinonasal papilloma is a common benign epithelial tumor of the sinonasal tract and accounts for 0.5% to 4% of all nasal tumors. The etiology of sinonasal papilloma remains unclear, although human papilloma virus has been proposed as a major risk factor. Other etiological factors, such as anatomical variations of the nasal cavity, may be related to the pathogenesis of sinonasal papilloma, because deviated nasal septum is seen in patients with chronic rhinosinusitis. We, therefore, investigated the involvement of deviated nasal septum in the development of sinonasal papilloma. Preoperative computed tomography or magnetic resonance imaging findings of 83 patients with sinonasal papilloma were evaluated retrospectively. The side of papilloma and the direction of septal deviation showed a significant correlation. Septum deviated to the intact side in 51 of 83 patients (61.4%) and to the affected side in 18 of 83 patients (21.7%). Straight or S-shaped septum was observed in 14 of 83 patients (16.9%). Even after excluding 27 patients who underwent revision surgery and 15 patients in whom the papilloma touched the concave portion of the nasal septum, the concave side of septal deviation was associated with the development of sinonasal papilloma (p = 0.040). The high incidence of sinonasal papilloma in the concave side may reflect the consequences of the traumatic effects caused by wall shear stress of the high-velocity airflow and the increased chance of inhaling viruses and pollutants. The present study supports the causative role of human papilloma virus and toxic chemicals in the occurrence of sinonasal papilloma.

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Section: Discussionmentioning

confidence: 99%

“…Unilateral inverted papilloma is associated with contralateral inflammation, and the degree of contralateral inflammation is greater than that seen in the other sinonasal tumors (Orlandi et al 2002). Inverted papilloma typically occurs within the ethmoid sinuses or near the ostium of the maxillary sinus.…”

Section: Discussionmentioning

confidence: 99%

Association between Septal Deviation and Sinonasal Papilloma

Nomura

Ogawa

Sugawara

et al. 2013

Tohoku J. Exp. Med.

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“…This degree of contralateral inflammation is greater than that seen for other sinonasal tumours. 26 Inflammatory cells have been identified as a significant cell population in inverted papilloma, whereas they are less commonly encountered in other types of nasal polyps. 28 A histological review even suggested inverted papilloma to be an inflammatory polyp rather than a true papilloma.…”

Section: Common Presentationsmentioning

confidence: 99%

“…25 Chronic inflammation may be involved in the pathogenesis of inverted papilloma. 26,27 Unilateral inverted papilloma is associated with contralateral inflammation, as detected by computed tomography (CT). This degree of contralateral inflammation is greater than that seen for other sinonasal tumours.…”

Section: Common Presentationsmentioning

confidence: 99%

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Sinonasal inverted papilloma: narrative review

2010

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In order to compare different studies and to enable meta-analysis of the literature, there should be a universally accepted staging and classification system for sinonasal inverted papilloma. Further research on the aetiology of sinonasal inverted papilloma, and on biological markers for its recurrence and malignant transformation, is required. To enable meaningful future research, we would encourage multicentre participation with a consensus on management.

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