Sirolimus‐associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient

Joo, Su Jin; Yıldırım, İnci; Stenger, Elizabeth; Anderson, Evan J.

doi:10.1111/petr.13425

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…One report discusses alemtuzumab [9]. Scattered reports, as well as the European Society of Cardiology guidelines, discuss cyclosporine-associated [8,14] and sirolimus-associated pericardial effusions [15]. Firstline treatment for SAA is triple immunosuppression with hATG, cyclosporine, and the thrombomimetic agent eltrombopag (rarely romiplostim) [16].…”

Section: Discussionmentioning

confidence: 99%

Pericardial Effusion: A Novel Presentation of Aplastic Anemia

Hall¹,

Leach²,

Altshuler³

et al. 2023

Cureus

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Pericardial effusion is defined as the accumulation of fluid between the visceral and parietal pericardium. The underlying etiology varies as any pathology that causes pericarditis or involves the pericardium can cause effusion. In practice, the majority of pericarditis cases are idiopathic, although these are assumed to be secondary to occult viral infection or inflammatory phenomena. Malignancy, particularly the metastatic spread of noncardiac primary tumors, has been implicated as a differential in the diagnosis of pericardial effusion. Though commonly seen in solid malignancies, effusion has been reported in hematologic malignancies such as myelodysplastic syndrome (MDS), acute leukemia, and lymphoma.Nonetheless, pericardial effusions associated with hematologic conditions are extremely rare with only one case report published describing pericardial effusion secondary to immune thrombocytopenia (ITP). We herein report the first documented case, to our knowledge, of pericardial effusion as an initial clinical manifestation of aplastic anemia in a middle-aged male presenting with pancytopenia.

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