Sirolimus-Eluting and Paclitaxel-Eluting Stents for Coronary Revascularization

Windecker, Stephan; Remondino, Andréa; Eberli, Franz R.; Jüni, Peter; Räber, Lorenz; Wenaweser, Peter; Togni, Mario; Billinger, Michael; Tüller, David; Seiler, Christian; Roffi, Marco; Corti, Roberto; Sütsch, Gabor; Maier, Willibald; Lüscher, Thomas F.; Hess, Otto M.; Egger, Matthias; Meier, Bernhard

doi:10.1056/nejmoa051175

Cited by 540 publications

(351 citation statements)

References 22 publications

Supporting

Mentioning

314

Contrasting

Unclassified

Order By: Relevance

“…Stent thrombosis remains a major concern after drug-eluting stent deployment because of its high morbidity and mortality. 5,6,43 TF may be induced by stenting and is a key factor in the pathogenesis of stent thrombosis 1 ; both antiproliferative agents used on drug-eluting stents, paclitaxel and rapamycin, do indeed enhance endothelial TF expression and thereby promote thrombus formation. 7,8 Similar to rapamycin and paclitaxel, cardiac glycosides exerts antiproliferative effects on human vascular smooth muscle cells, 12 but in contrast suppresses endothelial TF expression and thereby may reduce late stent thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Glycosides Regulate Endothelial Tissue Factor Expression in Culture

Stähli

Berndt

Akhmedov

et al. 2007

ATVB

View full text Add to dashboard Cite

Background-Tissue factor (TF) plays an important role in acute coronary syndromes and stent thrombosis. This study investigates whether Na ϩ /K ϩ -ATPase regulates TF expression in human endothelial cells. Methods and Results-Ouabain inhibited tumor necrosis factor (TNF)-␣-induced endothelial TF protein expression; maximal inhibition occurred at 10 Ϫ5 mol/L, reached more than 70%, and was observed throughout the 5 hours stimulation period. The decrease in protein expression was paralleled by a reduced TF surface activity. Similarly, lowering of extracellular potassium concentration inhibited TNF-␣-induced TF protein expression. In contrast, ouabain did not affect TNF-␣-induced expression of full-length TF mRNA for up to 5 hours of stimulation; instead, expression of alternatively-spliced TF mRNA was upregulated after 3 and 5 hours of stimulation. Ouabain did not affect TNF-␣-induced activation of the MAP kinases p38, extracellular signal-regulated kinase (ERK), and c-Jun terminal NH 2 kinase; activation of Akt and p70S6 kinase remained unaltered as well. Similar to the MAP kinases, ouabain did not affect TNF-␣-induced degradation of IB-␣. Ouabain had no effect on TF protein degradation. Conclusions-Naϩ /K ϩ -ATPase is required for protein translation of endothelial TF in culture. This observation provides novel insights into posttranscriptional regulation of TF expression. (Arterioscler Thromb Vasc Biol.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac Glycosides Regulate Endothelial Tissue Factor Expression in Culture

Stähli

Berndt

Akhmedov

et al. 2007

ATVB

View full text Add to dashboard Cite

show abstract

“…82,[107][108][109][110][111][112][113][114][115][116][117] Of these eight RCTs, only one (TAXi) was identified in our initial electronic search of bibliographic databases, five (SIRTAX, REALITY, ISAR-DIABETES, CORPAL, BASKET 82,107,108,[110][111][112][113][114][115][116][117] ) through handsearching activities and two (DOMINO and ISAR-TEST 118,119 ) from manufacturer submissions to NICE.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Drug-eluting stents: a systematic review and economic evaluation

Hill¹,

Boland²,

Dickson³

et al. 2007

Health Technol Assess

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) Programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as r...

show abstract

“…Many previous randomized studies have compared paclitaxel-and sirolimus-eluting stents [15][16][17][18][19][20][21][22][23][24][25] . However, in addition to the drug, the stents used in those studies differed in all other characteristics (coating and platform), which consequently prevented a more conclusive evaluation of the effects of the drugs themselves.…”

Section: Discussionmentioning

confidence: 99%