SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

Jin, Xinxin; Sun, Xulei; Ma, Xiao; Qin, Zixuan; Gao, Xin; Kang, Xiaomin; Li, Huixia; Sun, Hongzhi

doi:10.1007/s00018-023-05043-9

Cell. Mol. Life Sci.

2024

DOI: 10.1007/s00018-023-05043-9

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SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

Xinxin Jin,

Xulei Sun,

Xiao Ma

et al.

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2024

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Cited by 3 publications

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Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways

Qu,

Zhao,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

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Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways

Qu,

Zhao,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

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The role of GOT1 in cancer metabolism

Peng,

Dou,

et al. 2024

Front. Oncol.

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GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays a critical role in various metabolic pathways essential for cellular homeostasis and dysregulated metabolism. Recent studies have highlighted the significant plasticity and roles of GOT1 in metabolic reprogramming through participating in both classical and non-classical glutamine metabolism, glycolytic metabolism, and other metabolic pathways. This review summarizes emerging insights on the metabolic roles of GOT1 in cancer cells and emphasizes the response of cancer cells to altered metabolism when the expression of GOT1 is altered. We review how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT1 is inhibited and delineate the molecular mechanisms of GOT1’s interaction with specific oncogenes and regulators at multiple levels, including transcriptional and epigenetic regulation, which govern cellular growth and metabolism. These insights may provide new directions for cancer metabolism research and novel targets for cancer treatment.

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Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

Chen,

Xiao,

Liu

et al. 2024

Biomolecules

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Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important role of SIRT1 in bone homeostasis. This article reviews the role of SIRT1 in bone metabolism and OP and also discusses therapeutic strategies and future research directions for targeting SIRT1.

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SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

Cited by 3 publications

References 57 publications

Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways

Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways

The role of GOT1 in cancer metabolism

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

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