Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice

Sun, Zuhao; Zhao, Shuang; Suo, Xinjun; Dou, Yan

doi:10.1186/s12868-022-00718-8

Cited by 14 publications

(6 citation statements)

References 61 publications

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“…As reported, SIRT1 can promote the long-term survival of neurons; moreover, it can also protect and improve synaptic plasticity [41]. An animal experiment showed that knock-out of SIRT1 in the hippocampus of mice resulted in memory impairment, reduced secretion of neurons, decreased dendritic complexity, and perturbed synaptic plasticity in the mice, leading to depressionlike behaviors [42]. Another study reported that rats under CUMS exhibited reductions in the levels of BDNF, CREB, and SIRT1, increase in miR-134 expression, dendritic remodeling, and DG-CA3 system disorders, while BDNF has a crucial role in maintaining the dendrite length and branching homeostasis [43].…”

Section: Sirt1 Regulates Depression By Mediating Neurogenesismentioning

confidence: 89%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. Exercise is an important means to improve energy metabolism and depression, but it remains to be established how SIRT1 acts during exercise and improves depression. By induction and analysis, SIRT1 can be activated by exercise and then improve the function of the hypothalamic–pituitary–adrenal (HPA) axis by upregulating brain-derived neurotrophic factors (BDNF), inhibit the inflammatory response (suppression of the NF-κB and TNF-α/indoleamine 2,3-dioxygenase (IDO)/5-Hydroxytryptamine (5-HT) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (IGF-1) and growth-associated protein-43 (GAP-43) pathways, etc.), thereby improving depression. The present review gives a summary and an outlook based on this finding and makes an analysis, which will provide a new rationale and insight for the mechanism by which exercise improves depression.

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Section: Sirt1 Regulates Depression By Mediating Neurogenesismentioning

confidence: 89%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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“…SIRT1 is an important protective gene against hippocampal atrophy and its induced cognitive impairment during aging. 794 Surgery-induced downregulation of hippocampal SIRT1 participates in cognitive impairment after surgery by inhibiting the autophagy process and activating apoptosis. 795 Additionally, exposure to fluoride could lead to cognitive impairment, and the underlying mechanisms might be related to oxidative stress and mitochondrial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

288

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Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

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“…First, the key to diagnosis is distinguishing MCI from middle age to elderly population. MCI is mainly manifested as a decline in the function of single or multiple cognitive fields, but normal middle-aged and elderly population also shows a decline in cognitive ability due to factors such as reduced hippocampal volume and adverse changes in cerebrovascular structure ( Sun et al, 2022 ). Therefore, distinguishing MCI from normal aging-induced cognitive decline is a key issue in the clinical diagnosis of MCI ( Naidu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of motor-cognitive interaction based on dual-task gait analysis recognition in middle age to aging people with normal cognition and mild cognitive impairment

Zheng

Lang

Liang

et al. 2022

Front. Aging Neurosci.

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BackgroundMild cognitive impairment (MCI) is considered a transitional stage between cognitive normality and dementia among the elderly, and its associated risk of developing Alzheimer’s disease (AD) is 10–15 times higher than that of the general population. MCI is an important threshold for the prevention and control of AD, and intervention in the MCI stage may be the most effective strategy to delay the occurrence of AD.Materials and methodsIn this study, 68 subjects who met the inclusion criteria were divided into an MCI group (38 subjects) and normal elderly (NE) group (30 subjects). Both groups underwent clinical function assessments (cognitive function, walking function, and activities of daily living) and dual-task three-dimensional gait analysis (walking motor task and walking calculation task). Spatial-temporal parameters were obtained and reduced by principal component analysis, and the key biomechanical indexes were selected. The dual-task cost (DTC) was calculated for intra-group (task factor) and inter-group (group factor) comparisons.ResultsThe results of the principal component analysis showed that the cadence parameter had the highest weight in all three walking tasks. In addition, there were significant differences in the cadence both walking motor task (WMT) vs. walking task (WT) and walking calculation task (WCT) vs. WT in the MCI group. The cadence in the NE group only showed a significant difference between WMT and WT. The only differences between the MCI group and NE group was DTC cadence in WCT, and no differences were found for cadence in any of the three walking tasks.ConclusionThe results show that dual tasks based on cognitive-motor gait analysis of DTCcadence in MCI have potential value for application in early identification and provide theoretical support to improve the clinical diagnosis of MCI.

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Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice

Cited by 14 publications

References 61 publications

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

The sirtuin family in health and disease

Effects of motor-cognitive interaction based on dual-task gait analysis recognition in middle age to aging people with normal cognition and mild cognitive impairment

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