Sirtuins and the prevention of immunosenescence

Lasigliè, Denise

doi:10.1016/bs.vh.2020.12.011

Cited by 3 publications

(1 citation statement)

References 269 publications

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“…Sirtuins alter protein activity and stability through lysine deacetylation is another important factor in regulating the cellular aging process ( Lasigliè, 2021 ). The sirtuins SIRT1, SIRT3, and SIRT6 are key regulators of HSC lifespan ( Wang et al, 2016 ; Fang et al, 2020 ; Wang et al, 2022b ).…”

Section: Effects Of Ginseng On Different Types Of Stem Cellsmentioning

confidence: 99%

Ginsenosides on stem cells fate specification—a novel perspective

Liu

Jiang

Song

et al. 2023

Front. Cell Dev. Biol.

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Recent studies have demonstrated that stem cells have attracted much attention due to their special abilities of proliferation, differentiation and self-renewal, and are of great significance in regenerative medicine and anti-aging research. Hence, finding natural medicines that intervene the fate specification of stem cells has become a priority. Ginsenosides, the key components of natural botanical ginseng, have been extensively studied for versatile effects, such as regulating stem cells function and resisting aging. This review aims to summarize recent progression regarding the impact of ginsenosides on the behavior of adult stem cells, particularly from the perspective of proliferation, differentiation and self-renewal.

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Section: Effects Of Ginseng On Different Types Of Stem Cellsmentioning

confidence: 99%

Ginsenosides on stem cells fate specification—a novel perspective

Liu

Jiang

Song

et al. 2023

Front. Cell Dev. Biol.

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Sirt6 inhibits vascular endothelial cell pyroptosis by regulation of the Lin28b/let-7 pathway in atherosclerosis

Yao

Zhang

et al. 2022

International Immunopharmacology

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Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

Ziętara

Dziewięcka

Augustyniak

2022

IJMS

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The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries.

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Sirtuins and the prevention of immunosenescence

Cited by 3 publications

References 269 publications

Ginsenosides on stem cells fate specification—a novel perspective

Ginsenosides on stem cells fate specification—a novel perspective

Sirt6 inhibits vascular endothelial cell pyroptosis by regulation of the Lin28b/let-7 pathway in atherosclerosis

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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