Despite the concern about climate change and the associated negative impacts, fossil fuels continue to prevail in the global energy consumption. This paper aimed to propose the first model that relates CO2 emissions of Sao Paulo, the main urban center emitter in Brazil, with gross national product and energy consumption. Thus, we investigated the accuracy of three different methods: multivariate linear regression, elastic-net regression, and multilayer perceptron artificial neural networks. Comparing the results, we clearly demonstrated the superiority of artificial neural networks when compared with the other models. They presented better results of mean absolute percentage error (MAPE = 0.76%) and the highest possible coefficient of determination (R2 = 1.00). This investigation provides an innovative integrated climate-economic approach for the accurate prediction of carbon emissions. Therefore, it can be considered as a potential valuable decision-support tool for policymakers to design and implement effective environmental policies.