Sister chromatid exchanges in lymphocytes of patients with oral carcinoma

Bazopoulou-Kyrkanidou, Euterpe; Garas, J; Angelopoulos, A.

doi:10.1016/0165-4608(86)90105-6

Cited by 14 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results have been suggested by Shankarnarayan et al (1989). However, earlier Bazopoulou-Kyrkanidou et al (1986) reported * -Significant at (P<0.05) from the control ‡ -Significant at (P<0.01) from the control † -Significant at (P<0.001) from the control normal baseline SCE levels in the patients with this malignancy. One of the unusual findings of the present study was for 5 females with carcinoma of uterine & cervix, who showed normal SCE rates.…”

Section: Resultsmentioning

confidence: 66%

Some Observations on Spontaneous Sister Chromatid Exchange Frequencies and Cell Cycle Progression in Stimulated Lymphocytes of Patients With Different Malignancies

Gadhia

Vaniawala²,

Pithawala

et al. 2005

International Journal of Human Genetics

View full text Add to dashboard Cite

Total 23 patients with different malignancies viz. Ca. Lung (5), Ca. Uterine & Cervix (5), Ca. Head & Neck (5), Sarcomas (5) and Malignant Melanoma (3); were studied for spontaneous sister chromatid exchange frequencies (SCE) as well as cell cycle progression. All blood samples were collected prior to chemotherapy and/or radiotherapy to exclude the influence of these therapies, if any, on SCEs. Totally 15 healthy, age and sex matched individuals and belonging to the same socioeconomic status, but no direct relatives of the patients were studied simultaneously as controls. The SCE rates, when compared to controls (4.00 ± 0.39) were found to be significantly high for patients with Ca. lung (9.42 ± 1.20), malignant melanoma (8.14 ± 0.21), Ca. head & neck (6.85 ± 0.89) as well as sarcomas (6.29 ± 0.79). However, no detectable difference was observed in the SCE rate for patients with Ca. uterine & cervix (5.02 ± 0.88). Cell cycle proliferation and thereby replicative index was significantly elevated in patients with carcinoma of head & neck as well as malignant melanoma. On the other hand, rest of the patients showed no much variation in cell cycle progression when compared to controls.

show abstract

Section: Resultsmentioning

confidence: 66%

Some Observations on Spontaneous Sister Chromatid Exchange Frequencies and Cell Cycle Progression in Stimulated Lymphocytes of Patients With Different Malignancies

Gadhia

Vaniawala²,

Pithawala

et al. 2005

International Journal of Human Genetics

View full text Add to dashboard Cite

show abstract

Elevated sister chromatid exchange frequencies in the lymphocytes of esophageal cancer patients

Adhvaryu

Rawal

Patel

1988

Cancer

View full text Add to dashboard Cite

Thirty patients with esophageal cancer and 35 healthy controls were studied for spontaneous and mutagen-induced sister chromatid exchange (SCE) frequencies and cellular kinetics in peripheral blood lymphocytes. Some of the patients and controls were tobacco consumers (TC). A mean spontaneous SCE per cell value of 8.36 obtained for the patients was higher significantly (P less than 0.001) compared with a SCE per cell value of 6.74 for the controls. It was noticed that the elevation was significant even when persons in both groups were separated and compared on the basis of tobacco consumption. Among the controls, TC had higher SCE compared with non-tobacco consumers (NTC) (P less than 0.01). Mitomycin C (MMC) was used as a mutagen. No significant difference was observed in MMC-induced rates of SCE between the patients and controls. The cellular kinetics, expressed as average generation time (AGT), also were comparable in both groups. It was concluded that either metabolic stress imposed by the tumor or some clastogenic secretion of malignant cells was responsible for elevated SCE rates in the lymphocytes of the esophageal cancer patients. The disease had no effect on mutagen-induced SCE rates or cellular kinetics in lymphocytes.

show abstract

Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment

Davé

Trivedi

Adhvatyu

1992

Cancer

View full text Add to dashboard Cite

Background. Cytogenetic studies, framed to assess the possible genomic damage caused by areca nut consumption (without tobacco and not as a component of betel quid), were performed among areca nut chewers, which included normal people who chew areca nuts, patients with oral submucous fibrosis, and patients with oral cancer, and healthy nonchewing controls. Results. The analysis showed statistically significant increases in the frequencies of sister chromatid exchanges and chromosome aberrations in peripheral blood lymphocytes and the percentage of micronucleated cells in exfoliated cells of buccal mucosa among all three groups of chewers when compared with those of the controls. Conclusions. The current data, the first of this type among only areca nut chewers, highlight that this popular masticatory is erroneously considered “safe” and that it increases the genomic damage even when chewed without tobacco. The data also signify that, henceforth, in cytogenetic biomonitoring, areca nut consumption also should be considered as one of the confounding factors.

show abstract

Sister chromatid exchanges in lymphocytes of patients with oral carcinoma

Cited by 14 publications

References 12 publications

Some Observations on Spontaneous Sister Chromatid Exchange Frequencies and Cell Cycle Progression in Stimulated Lymphocytes of Patients With Different Malignancies

Some Observations on Spontaneous Sister Chromatid Exchange Frequencies and Cell Cycle Progression in Stimulated Lymphocytes of Patients With Different Malignancies

Elevated sister chromatid exchange frequencies in the lymphocytes of esophageal cancer patients

Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment

Contact Info

Product

Resources

About