Sister-chromatid exchanges in lymphocytes of workers at a phosphate fertilizer factory

Meng, Ziqiang; Meng, Huaqian; Cao, Xiulan

doi:10.1016/0165-1161(95)90017-9

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Furthermore, epidemiological studies demonstrated a significantly increased frequency of sister-chromatid exchange, chromosomal aberrations, and micronuclei among the fertilizer factory workers exposed to air pollution from phosphate fertilizers. Although fluorine (HF and SiF 4 ) was the main air pollutant in the investigated workplace, the workplace also contained ammonia (NH 3 ), sulfur dioxide (SO 2 ), and floating dust in small amounts, and their possible contribution towards the observed effects has been suggested [21,22]. Moreover, it could be plausibly proposed that these products of fertilizer decomposition and subsequent gasses could have been mutagenic agents leading to chromosomal abnormalities, depending on the composition of the fertilizer and condition of decomposition.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, exposure to organophosphate insecticides (OP) [16], air pollutants [17,18], and pyrethroids [19,20] were associated with chromosomal abnormalities in human reproductive cells. Furthermore, several studies demonstrated chromosomal abnormalities and other genetic effects associated with exposure to agrochemical fertilizers in fertilizer factory workers [21,22] and in exposed plant systems [23]. The products of fertilizer decomposition could also generate toxic products.…”

Section: Introductionmentioning

confidence: 99%

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Potential Increased Risk of Trisomy 18 Observed After a Fertilizer Warehouse Fire in Brazos County and TX

Zhang

Han

et al. 2020

IJERPH

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Background: In this paper, we aimed to investigate the potential impacts of a fire accident in a fertilizer warehouse on chromosomal anomalies, including Trisomy 21 (T21) and Trisomy (T18) among pregnancies in Brazos County, Texas. We conducted an observational study in Brazos County, TX, with all patients of T18 and T21 cases in the live births in Brazos County between 2005–2014. The prevalence of T18 and T21 before, during, and after the accident in Brazos County were calculated and compared. The Standardized Morbidity Ratio (SMR) was applied to compare the prevalence of T18 and T21 in Brazos County to the statewide prevalence in Texas after adjusting for maternal race and age. Compared with statewide risk, the risk of T18 during the impacted years in Brazos county was found to be significantly higher (SMR = 5.0, 95% Confidence Interval(CI): 2.19–9.89), while there was no significant difference before (SMR = 0.77, 0.13–2.54) and after the accident (SMR = 0.71, 0.12–2.36). However, the prevalence of T21 during the impacted years was not significantly different from those before or after the accident. This study conclusively suggests that this fertilizer fire may be related to the increased prevalence of T18 in Brazos County, though the findings warrant further investigation.

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Section: Discussionmentioning

confidence: 99%