Sisters of women with premature ovarian failure may not be ideal ovum donors

The incidence of both serious and minor complications in young women undergoing oocyte donation

“…In comparison to the present study, the Sung et al (29) study found an increased cancellation rate in sister donors compared with anonymous donors (4/13 vs. 4/66). Similar to the present study, however, Sung et al (29) found that all four sister donors were canceled as a result of poor ovarian response, vs. only two of four anonymous donors.…”

“…We observed a cancellation rate of 8.9% among anonymous donors (75/847) and one of 9.5% among directed donors (12/126). Our data extend previous data from Sung et al (29) on the differences in cancellation between anonymous and sister donors. In comparison to the present study, the Sung et al (29) study found an increased cancellation rate in sister donors compared with anonymous donors (4/13 vs. 4/66).…”

ESHRE Guideline: management of women with premature ovarian insufficiency

“…Oocyte donation is an established option for fertility in women with POI (Oyesanya, et al, 2009, Sauer, et al, 1994, Sung, et al, 1997, Templeton, et al, 1996.…”

Sibling and self ovum donation for sisters with an intermediate FMR1 mutation: what's a program to do?

“…[and] that their sisters may not be ideal ovum donors'' (14). A decade later, our evolving understanding of POF, FMR1 mutations, and a possible incremental path toward ovarian insufficiency justifies those authors' concerns, and highlights the dilemmas encountered in the management of our patient.…”