2023
DOI: 10.1002/elsc.202200064
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Site‐directed mutagenesis improves the practical application of L‐glutamic acid decarboxylase inEscherichia coli

Abstract: γ-Aminobutyric acid (GABA) is a kind of non-proteinogenic amino acid which is highly soluble in water and widely used in the food and pharmaceutical industries. Enzymatic conversion is an efficient method to produce GABA, whereby glutamic acid decarboxylase (GAD) is the key enzyme that catalyzes the process.The activity of wild-type GAD is usually limited by temperature, pH or biotin concentration, and hence directional modification is applied to improve its catalytic properties and practical application. GABA… Show more

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