Site of triggering of the accommodation reflex in man

Berghe, Pieter Vanden; Vos, Rita; Janssens, J; Tack, Jan

doi:10.1016/s0016-5085(00)82816-4

Cited by 7 publications

(12 citation statements)

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“…Therefore, signalling from gastric vagal tension receptors to the central nervous system is pivotal in the initiation of this motor pattern 37 . In contrast, nutrient‐related activation of gastro‐duodenal mucosal receptors is believed to be the main stimulus inducing proximal gastric relaxation by a meal 38–40 . Thus, our findings indicate that the signals from vagal gastric tension receptors to proximal gastric distension and the signals from vagal gastro‐duodenal mucosal receptors to nutrients are affected differently by baclofen.…”

Section: Discussionmentioning

confidence: 73%

Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans

Vos

Janssens

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: The c-aminobutyric acid receptor type B agonist, baclofen, inhibits transient lower oesophageal sphincter relaxations by influencing a vagal pathway. Although post-prandial proximal gastric function, which is vagally mediated, is important in the occurrence of transient lower oesophageal sphincter relaxations, the effects of baclofen on post-prandial proximal gastric motility in humans remains undetermined. Aim: To determine the effects of baclofen on postprandial lower oesophageal sphincter function and proximal gastric motility in healthy subjects. Methods: In 11 healthy volunteers, a barostat bag and an oesophageal manometric catheter with a sleeve were simultaneously positioned; 40 mg of oral baclofen or placebo was then given in a randomized, double-blind

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Section: Discussionmentioning

confidence: 73%

Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans

Vos

Janssens

et al. 2003

Aliment Pharmacol Ther

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“…The neural pathway initiating gastric accommodation to a meal is not entirely known. Gastric relaxation can be induced by nutrient perfusion into the oropharynx, into the stomach, or into the small intestine, 25 and is mediated through a vagovagally driven non-adrenergic non-cholinergic mechanism. 1 Both in vivo and in vitro studies suggest that the principal candidate neurotransmitters released by non-adrenergic noncholinergic neurones during gastric accommodation are NO and VIP.…”

Section: Discussionmentioning

confidence: 99%

Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans

Tack¹,

Demedts

Meulemans

et al. 2002

Gut

182

191

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Aims: In humans, impaired gastric accommodation is associated with early satiety and weight loss. In animals, accommodation involves activation of gastric nitrergic neurones. Our aim was to study involvement of nitric oxide in gastric accommodation and in meal induced satiety in humans. Methods: The effect of N G -monomethyl-L-arginine (L-NMMA) 4 mg/kg/h and 8 mg/kg/h on gastric compliance, on sensitivity to distension, and on gastric accommodation was studied with a barostat in double blind, randomised, placebo controlled studies. The effect of L-NMMA 8 mg/kg/h on meal induced satiety was studied using a drinking test. Results: L-NMMA had no significant effect on fasting compliance and sensitivity. Ingestion of a meal induced a relaxation of 274 (15) ml which was significantly smaller after L-NMMA 4 mg/kg/h (132 (45) ml; p=0.03) or L-NMMA 8 mg/kg/h (82 (72) ml; p=0.03). L-NMMA 8 mg/kg/h significantly decreased the amount of food ingested at maximum satiety from 1058 (67) to 892 (73) kcal (p<0.01). Conclusion: In humans, fasting gastric tone and sensitivity to distension are not influenced by nitric oxide synthase inhibition, but the gastric accommodation reflex involves activation of nitrergic neurones. Inhibition of nitric oxide synthase impairs accommodation and enhances meal induced satiety.

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“…Studies on healthy volunteers found no evidence of a cephalic phase, but showed that oropharyngeal and gastric exposure to an ingested meal contribute to triggering of the gastric accommodation reflex. 51 Dual intragastric balloon studies identified antral distension-induced relaxation of the proximal stomach as a likely contributor to the gastric phase of the accommodation reflex. 52 Several studies have shown that duodenal stimulation, including balloon distension, lipid infusion or acid infusion, is able to induce relaxation of the proximal stomach.…”

Section: Initiation Of the Accommodation Reflexmentioning

confidence: 99%