Site‐Selective Ser‐Hydrolase Labelling with a Luminescent Organometallic NCN–Platinum Complex

Abstract

The synthesis, spectroscopic properties and protein-binding studies of a novel luminescent organometallic NCN-platinum complex are described. The luminescent organometallic complex was linked to a serine hydrolase reactive phosphonate group by means of click chemistry, and was ex-

Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains

“…The desired product was not isolated under any of the conditions employed with unreacted azidoperfluorodecane and a black paramagnetic solid resulting from the decomposition of the complex. It has previously been noted that click reactions involving compounds with metal-chloride bonds are problematic [20].…”

Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

“…A platinum(II) complex has been modified with a phosphonate inhibitor to generate a site-specific luminescent labeling reagent [Pt(N^C^N)Cl] (11) for serine hydrolase. 23 Excitation of the complex results in emission at 490 nm in CH 2 Cl 2 . Incubation of cutinase and the complex leads to a loss of ester-hydrolysis activity of the enzyme, which has been ascribed to the occupation of its serine active site by the complex.…”

An Alkyne‐Appended, Click‐Ready PtII Complex with an Unusual Arrangement in the Solid State

“…These usually incorporate bulkier aromatic or exchange-inert ligands around the Pt coordination sphere to discourage Pt-alkyne interactions. [8] De Sousa et al reported a moderately unhindered propargyl-containing chloroquinoline derivative coordinated to Pt II . [9] By contrast, Parker and co-workers reported on the incompatibility of cis-[Pt(NH 3 ) 2 -(OH 2 ) 2 ] 2+ with a small alkyne-containing O,O'-bidentate ligand in aqueous solution.…”