Situación del cáncer gástrico en el mundo y en Chile

Csendes, Attila; Figueroa, Manuel

doi:10.1016/j.rchic.2016.10.014

Cited by 38 publications

(47 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that GC survival rates are higher when there are early detection and diagnosis 8 . In Chile, some authors highlight the experience gained during the last decade by medical teams specialized in GC both for diagnosis and management of post-surgery adverse events 27 . Given that GC is ranked as the first cancer death cause (ranked by ASMR) 5 among males in Chile, higher priority in the public health agenda was given for this country.…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer Mortality Trends in the Southern Cone: Disentangling age, period and cohort patterns in Argentina and Chile

Díaz

Icaza

Núñez

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Although Argentina and Chile are neighboring countries, gastric cancer (GC) is the first cancer death cause in the Chilean male population, while it is ranked in fifth place for Argentinean males. This study is the first to identify the differential time-patterns associated with the age-period-cohort effects for the last few decades (1990-2015) in these Southern Cone countries. Trends of age-standardized truncated mortality rates (ASMR) for GC were analyzed using log-linear Poisson age-period-cohort models, including cubic splines for each component. The ASMR trends for GC decreased in both sexes but more considerably in Chile and more favorably for males (annual percentage changes 2002-2015 = −3.5, 95%CI: −3.9 to −3.1). Moreover, GC age-specific mortality rates were noticeably higher in Chile. A favorable decreasing mortality risk throughout the periods (from 2000) and by cohort was observed for both countries; however, the risk reduction has stabilized in younger female cohorts since 1950-cohort. In conclusion, overall favorable decreasing trends for GC mortality were found; however, when ageperiod-cohort effects were disentangled, Chile and younger female cohorts showed a more unfavorable scenario. Obesity, lifestyles, and environmental conditions (like altitude) may explain country differences. This analytical approach may be a valuable tool to be replicated in other countries with no population-based cancer registries and acceptable mortality data quality. Gastric cancer (GC) is one of the five most frequent cancers (excluding non-melanoma skin cancer) in the world 1,2 and the third leading cause of cancer death in both sexes worldwide 1. Although GC mortality rates have been declining over the last few decades, the rates in several countries in South America and Asia remain the highest in the world 3. The number of deaths in Latin America and the Caribbean attributable to this cancer is among the highest in the world; South America is the third region with one of the highest age-standardized (World Standard Population) incidence rates for GC, preceded only by Eastern Asia and Central and Eastern Europe 1. Characteristics of the Southern Cone that distinguish it from the northern area of South America include unusually high consumption of meat, mainly barbecued, and wine consumption, which has already been reported as associated with cancer 4. However, Chile and Argentina are among the countries in South America with the highest and lowest age-standardized mortality rates (ASMR) for both sexes, respectively (ranked in third and 23th place among the 32 countries in the region), with overall ASMR equals of 17.9 and 6.4 per 100,000 in men and women for Chile, and 7.5 and 3.0 for Argentina, respectively 5. Thus, even though they are neighboring countries in the Southern Cone with similar reports of the human development index and behaviors, the health differences between these countries should be analyzed. Helicobacter pylori (H. pylori) infection is a primary risk factor of GC. It is estimated that about half o...

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric Cancer Mortality Trends in the Southern Cone: Disentangling age, period and cohort patterns in Argentina and Chile

Díaz

Icaza

Núñez

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…La situación del cáncer gástrico en Chile ha sido publicada recientemente por nosotros 8 . A pesar que las tasas de mortalidad se mantienen sin cambios, llamó la atención un aumento de las operaciones y una baja en la mortalidad operatoria.…”

Section: Discussionunclassified

Evolución de operaciones por enfermedades del intestino proximal y glándulas anexas realizadas en Chile entre 2011 y 2016

Figueroa-Giralt

et al. 2019

Rev. cir.

View full text Add to dashboard Cite

Evolution of surgeries due to diseases of the proximal intestine and anexal glands perfomed in Chile between 2011 and 2016 Introduction: The number of operations performed in Chile due to diseases for the foregut, have been every time more precise and complete in the National Register Data of Statistics in Health (MINSAL), and published in several reports (years 1983, 2005 and 2011). Objectives: a) to incorporate data of new operations not included before and b) to compare the results of high complex operations reported on 2011 and 2016. Material and Methods: from the DEIS (Department of Statistics and Information of Health) we obtained the total number of operations performed during 2016, and the operative mortality at the time of discharge from the hospital for different diseases of the foregut been the majority malignant tumors: esophageal cancer, gastric cancer, pancreatic cancer, liver and bile ducts carcinoma, and cancer of the gallbladder. The results were compared to dose obtained the year 2011. Results: The annual lethality of digestive malignant tumors showed an increase in pancreatic and liver cancer, while a decrease was observed in patients with esophageal cancer al gallbladder cancer. Operations for benign pathology like esophagomiotomy and laparoscopic antireflux surgery showed no mortality, as well as gastric bypass. Laparoscopic cholecistectomy, and laparoscopic sleeve gastrectomy presented a very low mortality. Surgical procedures for malignant diseases showed a decrease in operative mortality compare to 2011, although not significant. Conclusions: The present study shows an increase in the operations for foregut diseases performed during 2016 compared with the year 2011, as well as a decrease in operative mortality.

show abstract

“…La presentación y tratamiento del cáncer gástrico ha cambiado en los últimos 40 años. La frecuencia de tumores distales disminuyó de 64% a 25%, la proporción de tipo intestinal:difusa pasó de 3-4:1 a casi 1:1, la tasa de resecabilidad ha aumentado de 48% a 85% (p < 0,001), un 75% de los casos son gastrectomías totales y la mortalidad quirúrgica ha disminuido de 25% a 0,8% (p < 0,0001) 1,13 .…”

Section: Discussionunclassified

“…pronósticos objetiva que las variables significativas son: índice N+/T (p = 0,0001, OR: 1,1 [1,12]), LNR (p = 0,0001, OR: 5,8 [1,[4][5][6][7][8][9][10][11][12][13][14][15]6]), edad (p = 0,008, OR: 1,03 [1,00-1,06]), permeación linfovascular (p = 0,0001, OR: 2,19 [1,49-3.23]), clasificación T (p = 0,03, OR: 3,4 [1,93]), clasificación N (p = 0,001, OR: 1,06 [1,02-1,10]) y estadio TNM (p = 0,004, OR: 1,03 [1,06]). Las curvas ROC del índice N+/T, LNR y clasificación T poseen áreas bajo la curva de 0,789, 0,786 y 0,790 respectivamente, sin diferencia estadística significativa (p = 0,96).…”

Section: Técnica Quirúrgicaunclassified

Factores pronósticos de sobrevida alejada en cáncer gástrico. Introducción del nuevo índice N+/T

Figueroa-Giralt

2018

Rev Chil Cir

View full text Add to dashboard Cite

Prognostic factors of long term survival in gastric cancer. Introduction of the new N+/T index Background: The identification of survival prognostic factors for gastric cancer, allows us to create clinical guidelines. Chile has a deficit in the analysis of long-term survival prognostic factors. Aim: To assess different prognostic factors of long-term survival in gastric cancer. Determine the survival rate at 5 and 10-years post gastrectomy, and the value of a new prognostic factor of long-term survival called N+/T. Material and Method: Prospective study of the oncological database of the Clinical Hospital of the University of Chile between May 2004 and May 2012. Results: A total of 284 patients were included, 65.4% were men and the mean age was 64.5 years. Seventy-five percent were advanced gastric cancer, 72.5% of the patients required a total gastrectomy. The lymphadenectomy practiced was D2 in 85.2%, and average lymph node harvest was 30 lymph nodes. The postoperative morbidity and mortality was 17.2% and 1.7% respectively. The average global survival was 69.9 months, the 5-year survival was 56.9% and the 10-year survival was 53.4%. The N+/T index presented a statistically significant difference in the global survival of all the subgroups (p < 0.0001). The multivariate analysis showed that the significant variables were: N+/T index (p = 0.0001, OR

show abstract

Situación del cáncer gástrico en el mundo y en Chile

Cited by 38 publications

References 23 publications

Gastric Cancer Mortality Trends in the Southern Cone: Disentangling age, period and cohort patterns in Argentina and Chile

Gastric Cancer Mortality Trends in the Southern Cone: Disentangling age, period and cohort patterns in Argentina and Chile

Evolución de operaciones por enfermedades del intestino proximal y glándulas anexas realizadas en Chile entre 2011 y 2016

Factores pronósticos de sobrevida alejada en cáncer gástrico. Introducción del nuevo índice N+/T

Contact Info

Product

Resources

About