Situs inversus totalis with embryonal cell carcinoma of ovaries

Ibrahim, E. M.; Al‐Idrissi, Hassan Y.; Al-Farag, A.; Al-Tamimi, Dalal M.; Perry, Wayne

doi:10.1016/0090-8258(84)90036-2

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…1. Most cases (73%) were of single malignancies, in patients with CSI (4–31). There were nine cases of cancer in patients with SA (34–41), and only one (aside from the present case) reported multiple tumors in the same individual (34).…”

Section: Discussionmentioning

confidence: 48%

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Multiple primary malignancies in a patient with situs ambiguus

et al. 2006

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Section: Discussionmentioning

confidence: 48%

“…In addition to our current case, an additional 41 reports of cancer in patients with complete situs inversus (CSI) or SA were identified in the English literature from 1980 to July 2005, using the computerized PubMed database (4–41). Their distribution is illustrated in Fig.…”

Section: Discussionmentioning

confidence: 99%

Multiple primary malignancies in a patient with situs ambiguus

et al. 2006

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“…7 On the contrary, only a few cases of successful surgical treatments in SIT patients of esophageal cancer, pancreatic cancer, or ovarian cancer have been reported. [8][9][10] To our knowledge, report of SIT combined with gallbladder cancer has been rare. Here, we describe a successful case of radical resection of gallbladder cancer in a SIT patient.…”

Section: Introductionmentioning

confidence: 91%

Gallbladder Adenosquamous Cancer with Situs Inversus Totalis: A Case Report and Literature Review

Huang¹,

Yang²,

Wang³

et al. 2021

OTT

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Background Situs inversus totalis (SIT) is a rare genetic congenital disease, characterized with complete right-to-left inversion of all the internal organs. We herein describe a meaningful case which was diagnosed as gallbladder adenosquamous carcinoma, a rare histology type of gallbladder cancer, with SIT. Case Presentation A 59-year-old Chinese woman was admitted for persistent epigastric distention and intermittent abdominal pain. The abdominal CT scan revealed a huge mass at the gallbladder bottom, involving the adjacent transverse colon and liver. En-bloc radical resection of the gallbladder cancer, including partial colectomy and hepatectomy with regional node dissection, followed by colocolostomy and Roux-en-Y choledochojejunostomy, was successfully performed. Pathology analysis indicated an adenosquamous carcinoma with positive adenocarcinoma markers (CK7, CK19) and squamous carcinoma markers (CK5/6, P63). Conclusion The SIT anomaly might increase the risk of malignancies by sharing genome mutations, suggesting the importance of surveillance in the SIT settings.

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“…Malignant disease may occur in association with SI, although the condition itself should in no way be considered premalignant. Reports have included linitis plastica (Lukash and Wentz, 1968), bronchogenic carcinoma (Baruah and Chari, 1952), adenocarcinoma of the rectum (Wright and Morton, 1971), embryonal cell carcinoma of the ovaries (Ibrahim et al, 1984), renal cell carcinoma (Bertini and Boileau, 1987), carcinoma of the gall bladder (Shank and Stafford, 1953), and hepatocellular carcinoma (Kanematsu et al, 1983). T h e case reports all revealed the importance of early recognition of visceral transposition in the treatment of the concomitant disease, especially when there were surgical implications.…”

Section: Special Problems Of Diagnosis and Managementmentioning

confidence: 99%

Transposition of the viscera: A review

Brassett

Ellis

1991

Clinical Anatomy

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Situs inversus and its associated syndromes have fascinated anatomists, embryologists, and clinicians for centuries. However, the embryogenesis and mode of inheritance of situs inversus have remained ill-understood. In this review, we summarize the current knowledge regarding etiology and genetics, discuss the diagnostic features which may be clinically useful in identifying asymptomatic subjects, and outline some important aspects in the management of patients with visceral transposition and concomitant disease. The relevance of pre-and neonatal diagnosis of the condition is also evaluated. We conclude with some data on the incidence of situs inversus in the East Anglian region of England.

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Situs inversus totalis with embryonal cell carcinoma of ovaries

Cited by 12 publications

References 3 publications

Multiple primary malignancies in a patient with situs ambiguus

Multiple primary malignancies in a patient with situs ambiguus

Gallbladder Adenosquamous Cancer with Situs Inversus Totalis: A Case Report and Literature Review

Transposition of the viscera: A review

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