SIVmac pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans

Ling, Binhua; Veazey, Ronald S.; Luckay, Amara; Penedo, Cecilia; Xu, Keyu; Lifson, Jeffrey D.; Marx, Preston A.

doi:10.1097/00002030-200207260-00005

Cited by 207 publications

(187 citation statements)

References 21 publications

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“…However, several researches of Chinese rhesus macaques focused on the morphometrics (3) and genetic background (4) differences comparing with their Indian counterparts. Compared with Indian rhesus macaques, SIV(mac) pathogenesis in Chinese rhesus macaques was closer to HIV-1 infections in untreated adult humans (12). So Chinese rhesus macaques may be a better model used in AIDS research.…”

Section: Discussionmentioning

confidence: 98%

The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

et al. 2009

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Section: Discussionmentioning

confidence: 98%

The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

et al. 2009

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“…These findings support the idea that controlling SIV inside Mes LNs may be crucial. Given that Indian rhesus macaques (the predominant model of AIDS) progress more rapidly to disease than Chinese monkeys, 22,23 the observations performed on macaques #272, that closely resemble the infection pace in Indian macaques, provided an interesting example of viral dissemination throughout the body associated with a poor prognostic. Thus, our data showing distinct rates of disease progression in Chinese macaques suggest the importance of host factors in the control of viral dissemination.…”

Section: Discussionmentioning

confidence: 99%

TGF-β in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus

et al. 2007

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SIV-infected macaques exhibit distinct rates of progression to AIDS and despite significant increases in CD8 þ T cells, immune cells fail to control and eradicate SIV in vivo. Here, we investigated the interplay between viral reservoir sites, CD8 þ T-cell activation/death and outcome. Our data provide strong evidence that mesenteric (Mes) lymph nodes represent major reservoirs not only for SIV-infected macaques progressing more rapidly toward AIDS but also in controllers. We demonstrate that macaques progressing faster display greater expression of TGF-b and Indoleamine 2,3 dioxygenase in particular in intestinal tissues associated with a phosphorylation of the p53 protein on serine 15 in CD8 þ T cells from Mes lymph nodes. These factors may act as a negative regulator of CD8 þ T-cell function by inducing a Bax/Bak/Puma-dependent death pathway of effector/ memory CD8 þ T cells. Greater T-cell death and viral dissemination was associated with a low level of TIA-1 þ expressing cells. Finally, we provide evidence that abrogation of TGF-b in vitro enhances T-cell proliferation and reduces CD8 þ T-cell death. Our data identify a mechanism of T-cell exhaustion in intestinal lymphoid organs and define a potentially effective immunological strategy for the modulation of progression to AIDS. Cell Death and Differentiation (2007) 14, 1747-1758; doi:10.1038/sj.cdd.4402192; published online 6 July 2007Virus production in Human Immunodeficiency Virus 1 (HIV-1)-infected individuals is largely the result of a dynamic process involving continuous rounds of de novo infection and replication in CD4 þ cells with rapid turnover of both free virus and virus producing cells. Moreover, an increasing body of evidence suggests that reservoirs, cell types or anatomical sites ('sanctuaries'), represent a major barrier to virus eradication. 1 HIV-specific CD8 þ T lymphocytes (CTL) are considered crucial in the control of viral replication. 2 Excessive induction of apoptosis has been proposed as one major mechanism of abnormal T-cell response during HIV and Simian Immunodeficiency Virus (SIV) infections. 3 However, most studies, which investigated the potential relationship between HIV and SIV infections and apoptosis have focused on cells from peripheral blood, rather than on cells from lymphoid organs.Peripheral lymphoid tissues such as the axillary and inguinal (Ing) lymph nodes (LNs), which drain the arms and legs, respectively, and the spleen, are considered major sites of HIV/SIV replication. 4 Accumulating data also indicate that gut-associated lymphoid tissue (GALT), which contains inductive sites, Peyer's patches and mesenteric (Mes) LNs, and effectors sites located within lamina propria and epithelium of the intestinal wall, is also an early and predominant tissue site of viral replication and may be a reservoir for HIV/SIV. 5,6 Because T cells from the GALT are required to maintain a state of immunological tolerance toward a myriad of dietary and resident bacterial antigens, the chronic exposure of HIV/ SIV-specific antigens coul...

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“…In this study, we examined the reactivity, distribution, and specificity of OPD4 in rhesus macaques (Macaca mulatta) of both Chinese and Indian origin, as well as Pigtail macaques (Macaca nemestrina). Although they differ somewhat with respect to their response to SIV infection [16] both Indian and Chineseorigin rhesus macaques are currently considered the same genus and species (Macaca mulatta) and both are widely used in nonhuman primate studies of AIDS and other diseases. Similarly, pigtailed macaques are widely used as a model for AIDS.…”

Section: Introductionmentioning

confidence: 99%

Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques

Wang

Pahar

Rasmussen

et al. 2008

Developmental & Comparative Immunology

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Immunologic research in nonhuman primates is occasionally limited by the availability of reagents that cross react in nonhuman primates. One major limitation has been the lack of a monoclonal antibody to CD45RO. Although the monoclonal antibody UCHL-1 is used to detect CD45RO isoforms in humans, it does not react with nonhuman primates, mandating the use of alternative strategies to define "memory" T cell responses in nonhuman primates. The current study examined the reactivity and specificity of another antibody against CD45RO, clone OPD4, in macaques. Here we demonstrate that OPD4 specifically labels memory CD4+ T cells in ~44% of rhesus macaques (Macaca mulatta) of Indian, but not Chinese origin. In contrast, tissues from pigtail macaques (Macaca nemestrina) react with this clone, indicating that OPD4 may be useful for examining memory CD4+ T cells in certain macaques, but its utility may be limited in other species or even among individual macaques.

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SIVmac pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans

Cited by 207 publications

References 21 publications

The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

TGF-β in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus

Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques

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