Six cases of confluent and reticulated papillomatosis alleviated by various antibiotics

Confluent and reticulated papillomatosis (Gougerot-Carteaud) successfully treated with tacalcitol

“…Those bacteria or its products (bacterial superantigens) could induce the epidermal proliferative changes of CRP (cited by ref. 20). However, to date, there is no demonstration of bacteria as the cause of CRP.…”

“…9,15,17,18 In addition to the weakness of fungal theory and the very satisfactory response to retinoids and calcipotriol, the presence of an abnormality in the transitional cells between the stratum granulosum and corneum seen on electron-microscopy also suggests that CRP could be a keratinization disorder. 19 Recently, Jang et al 20 have reported a satisfactory response with various antibiotic regimens in six cases of CRP, suggesting that bacteria may play a role in the pathogenesis of this disease. Those bacteria or its products (bacterial superantigens) could induce the epidermal proliferative changes of CRP (cited by ref.…”

“…'Cyclines' (particularly minocycline) and macrolides have been the most frequently utilized. 12,15,17,20,[22][23][24] Whether the effectiveness of the antibiotics is determined by their anti-in ammatory and/or immunosuppresive properties or by their antibiotic action is debated. 12,17,20 Oral retinoids are also very effective, achieving a fast and complete response, with lasting remissions, but their use is restricted by their adverse side effects.…”

“…12,15,17,20,[22][23][24] Whether the effectiveness of the antibiotics is determined by their anti-in ammatory and/or immunosuppresive properties or by their antibiotic action is debated. 12,17,20 Oral retinoids are also very effective, achieving a fast and complete response, with lasting remissions, but their use is restricted by their adverse side effects. [4][5][6][7] Recently, topical calcipotriol, a vitamin D analogue, was successfully introduced as treatment for CRP.…”

Successful treatment of confluent and reticulated papillomatosis with tetracycline and mupirocin

“…Malassezia colonization can be detected, and improved with antifungal treatment. However, there are many CRP cases of undetected Malassezia or unresponsive to antifungal therapy 4 . We did not find any etiology related to CRP.…”