Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage

Kodama, Tetsuro; Shimosato, Yukío; Watanabe, Shaw; Koide, Tsutomu; Naruke, Tsuguo; Shimase, Junji

doi:10.1097/00000478-198410000-00002

Cited by 92 publications

(46 citation statements)

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“…Recent schemas define it as a subset of [12,13] or as an entity distinct from [3,6,14 -16] pulmonary blastoma. Defining pulmonary blastoma as a lung tumor that mimics developing lung [5], the term "pulmonary blastoma" may encompass the following: (1) classic biphasic blastoma, composed of malignant glands and malignant stroma [5,17]; (2) well-differentiated fetal adenocarcinoma, comprised only [18,19] or predominantly [17] of malignant epithelium; and (3) PPB, consisting of malignant stroma with or without accompanying benign epithelium [3,5].…”

Section: Discussionmentioning

confidence: 99%

Gains of Chromosome 8 Are Confined to Mesenchymal Components in Pleuropulmonary Blastoma

Vargas

Nosé

Fletcher

et al. 2001

Pediatric and Developmental Pathology

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Pleuropulmonary blastoma, an aggressive tumor that is emerging as a distinct entity of childhood, is characterized by mesenchymal elements (including undifferentiated blastema and often cartilaginous, rhabdomyoblastic, or fibroblastic differentiation) and epithelium-lined spaces. We investigated two patients with pleuropulmonary blastoma, a 3-year-old boy and an 11-year-old girl, both with large cystic masses replacing one lung. In both children, the post-chemotherapy resection specimens showed more maturation of rhabdomyoblasts and more nuclear pleomorphism in all mesenchymal cell lines, compared with biopsies sampled before treatment. Karyotypic analysis demonstrated gains in chromosome 8 in both cases and 17p deletion in one case. Fluorescent in situ hybridization analysis demonstrated that the chromosome 8 gains were present in all mesenchymal elements, including undifferentiated blastematous, rhabdomyoblastic, fibroblastic, and chondroblastic areas. Epithelial cells showed no chromosome 8 gains. The chromosome 8 aberrations were not appreciably different in pre- versus post-chemotherapy tissue. Our findings substantiate previous reports that polysomy of chromosome 8 is a consistent feature of pleuropulmonary blastoma. Further, they indicate that clonal proliferation in pleuropulmonary blastoma is restricted to the malignant mesenchymal elements, supporting the notion that the epithelial components of this tumor are non-neoplastic.

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Section: Discussionmentioning

confidence: 99%

Gains of Chromosome 8 Are Confined to Mesenchymal Components in Pleuropulmonary Blastoma

Vargas

Nosé

Fletcher

et al. 2001

Pediatric and Developmental Pathology

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“…On the other hand, we evaluated glycogen levels in the cancerous and noncancerous tissues of human lung by measuring the areas of glycogen band at 1045 cm Ϫ1 due to the OH stretching coupled with bending (1) and reported that the glycogen levels in the cancerous tissues are significantly higher than those in the noncancerous tissues (9). Furthermore, it has been suggested that the amount of cholesterol in malignant tissues is lower than that in the normal tissue (22)(23)(24)(25). Thus the decreased methylene band at 1467 cm Ϫ1 observed in the cancerous section might reflect decrease in the cholesterol levels (13,14) due to the degree of malignancy.…”

Section: Figmentioning

confidence: 99%

Direct Measurement of Human Lung Cancerous and Noncancerous Tissues by Fourier Transform Infrared Microscopy: Can an Infrared Microscope Be Used as a Clinical Tool?

Yano

Ohoshima

Gotou

et al. 2000

Analytical Biochemistry

132

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“…53 Interestingly, occult neuroendocrine differentiation is a rather common finding in the epithelial component of PB, with potential histochemical argyrophilia and immunoreactivity for endocrine markers. 71,72 A significant overlap exists between classic PB and the tumor described as pulmonary endodermal tumor resembling fetal lung or well-differentiated adenocarcinoma simulating fetal lung (Fig 11), which differs only in its relative lack of a malignant stromal component and more frequent synthesis of a particular oncofetal determinant, alpha-fetoprotein. 30,69,[71][72][73][74] Therefore, the latter lesion probably merely represents a peculiar polar extreme of the same spectrum of neoplasms in which PB resides; namely, that of sarcomatoid carcinomas in general.…”

Section: Pulmonary Blastomamentioning

confidence: 99%

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

Wick

Ritter

Humphrey

1997

American Journal of Clinical Pathology

104

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Sarcomatoid carcinomas ( S O of the lung are the most common pulmonary neoplasms that exhibit a composition by spindled or pleomorphic tumor cells. As such, many of them may be confused easily with true sarcomas diagnostically unless special immunohistological or ultrastructural analyses are performed. Reactivity is expected for keratin, epithelial membrane antigen, or collagen type IV in the sarcomalike elements in SC, although it may be focal. Electron microscopy often shows the presence of junctional complexes between tumor cells, with or without pericellular basal lamina and cytoplasmic skeins of intermediate filaments. Current terminological preferences are such that several formerly used terms-including "spindle-cell carcinoma," "pulmonary blastoma," " s q u a m o u s cell carcinoma w i t h p s e u d o s a r c o m a t o u s stroma," "pseudosarcoma," and "carcinosarcoma" Therefore, a cytologically atypical spindle cell tumor of the lung is usually considered an SC unless rigorous immunohistologic and ultrastructural studies indicate otherwise. The goal of this review is to provide a discussion of neoplasms in this general category, using information taken from the pertinent literature and our personal experience. HISTORICAL AND TERMINOLOGICAL CONSIDERATIONSA historical controversy has existed about the mechanisms by which obvious foci of carcinoma of the lung are commingled with malignant but nondescript spindle cell elements or tissues with the apparent morphotype of a particular sarcoma pattern. Also, From the Lauren V.

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Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage

Cited by 92 publications

References 0 publications

Gains of Chromosome 8 Are Confined to Mesenchymal Components in Pleuropulmonary Blastoma

Gains of Chromosome 8 Are Confined to Mesenchymal Components in Pleuropulmonary Blastoma

Direct Measurement of Human Lung Cancerous and Noncancerous Tissues by Fourier Transform Infrared Microscopy: Can an Infrared Microscope Be Used as a Clinical Tool?

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

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