Six-stage cascade paramagnetic mode magnetophoretic separation system for human blood samples

Jung, Yoon Young; Choi, YongMan; Han, Ki-Ho; Frazier, A. Bruno

doi:10.1007/s10544-010-9416-3

Cited by 39 publications

(30 citation statements)

References 46 publications

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“…There are examples reviewed in this paper where a gradient or a change in susceptibility can affect the magnetic field. For instance, ferromagnetic solid structures can trap the field lines and generate a magnetic field gradient (Han 2006, Jung et al 2010. This idea can be extended to magnetic fluid such as ferrofluid.…”

Section: Discussionmentioning

confidence: 99%

“…The field was strong enough to separate paramagnetic red blood cells and diamagnetic white blood cells. With multiple stages, the sorting efficiency of this concept was improved significantly (Jung et al 2010) (Fig. 8c).…”

Section: Magnetophoresismentioning

confidence: 99%

“…This concept mimics Fig. 8 Manipulation concepts based on magnetophoresis: a free-flow magnetophoresis (Pamme 2004); b sorting with magnetic gradient induced by a ferromagnetic structure (Han 2006); c multi-stage sorting with magnetic gradient induced by a ferromagnetic structure (Jung et al 2010); d sorting with ferromagnetic stripes (Adams et al 2008); e trapping with magnetic gradient induced by sharp poles (Kang 1784); f sorting with a gradient of susceptibility (Kang et al 2008); g sorting with electromagnetic stripes (Joung et al 2000); h trapping transport with wire loop created by addressable current conducting lines ; i trapping and transport with sawtooth conducting wires (WirixSpeetjens 1944); j trapping and transport with meandering conducting wires (Deng et al 2001) microorganisms that use rotational flagella and cilia to swim. Figure 9 summarizes the typical parameters of the above magnetic micro-swimmers.…”

Section: Magnetophoresismentioning

confidence: 99%

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Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Nguyen

2011

Microfluid Nanofluid

345

169

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Micro-magnetofluidics refers to the science and technology that combines magnetism with microfluidics to gain new functionalities. Magnetism has been used for actuation, manipulation and detection in microfluidics. In turn, microfluidic phenomena can be used for making tunable magnetic devices. This paper presents a systematic review on the interactions between magnetism and fluid flow on the microscale. The review rather focuses on physical and engineering aspects of micro-magnetofluidics, than on the biological applications which have been addressed in a number of previous excellent reviews. The field of micromagnetofluidics can be categorized according to the type of the working fluids and the associated microscale phenomena of established research fields such as magnetohydrodynamics, ferrohydrodynamics, magnetorheology and magnetophoresis. Furthermore, similar to microfluidics the field can also be categorized as continuous and digital micro-magnetofluidics. Starting with the analysis of possible magnetic forces in microscale and the impact of miniaturization on these forces, the paper revisits the use of magnetism for controlling fluidic functions such as pumping, mixing, magnetowetting as well as magnetic manipulation of particles. Based on the observations made with the state of the art of the field micro-magnetofluidics, the paper presents some perspectives on the possible future development of this field. While the use of magnetism in microfluidics is relatively established, possible new phenomena and applications can be explored by utilizing flow of magnetic and electrically conducting fluids.

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Section: Discussionmentioning

confidence: 99%

Section: Magnetophoresismentioning

confidence: 99%

Section: Magnetophoresismentioning

confidence: 99%

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Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Nguyen

2011

Microfluid Nanofluid

345

169

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“…These forces include hydrodynamic drag force, gravitational force, and magnetic force. There are varying assumptions made by researchers in this field but the ones that are the most common are a Newtonian fluid (for the sample or the buffer solution), 6 spherical magnetic particles, 21 non-rotational, 22 no slip conditions for the walls of the device, 23 and laminar flow. 24,25 The governing equations are Navier-Stokes for fluid flow and Maxwell's equations for magnetic fields.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Magnetophoretic-based microfluidic device for DNA isolation

Hale

Darabi

2014

Biomicrofluidics

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This paper presents a continuous flow microfluidic device for the separation of DNA from blood using magnetophoresis for biological applications and analysis. This microfluidic bio-separation device has several benefits, including decreased sample handling, smaller sample and reagent volumes, faster isolation time, and decreased cost to perform DNA isolation. One of the key features of this device is the use of short-range magnetic field gradients, generated by a micro-patterned nickel array on the bottom surface of the separation channel. In addition, the device utilizes an array of oppositely oriented, external permanent magnets to produce strong long-range field gradients at the interfaces between magnets, further increasing the effectiveness of the device. A comprehensive simulation is performed using COMSOL Multiphysics to study the effect of various parameters on the magnetic flux within the separation channel. Additionally, a microfluidic device is designed, fabricated, and tested to isolate DNA from blood. The results show that the device has the capability of separating DNA from a blood sample with a purity of 1.8 or higher, a yield of up to 33 lg of polymerase chain reaction ready DNA per milliliter of blood, and a volumetric throughput of up to 50 ml/h. V C 2014 AIP Publishing LLC.

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“…Another optofluidic bio-analysis platform involves a multi stage separation system that separated a cell mixture in blood based on their magnetic susceptibility properties. 198 The platform separated red and white human blood cells using the magnetophoretic force while fluorescent imaging was used to trace the particle separation efficiencies.…”

Section: Optofluidics For the Transport And Analyses Of Biological Comentioning

confidence: 99%

Optofluidics incorporating actively controlled micro- and nano-particles

et al. 2012

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The advent of optofluidic systems incorporating suspended particles has resulted in the emergence of novel applications. Such systems operate based on the fact that suspended particles can be manipulated using well-appointed active forces, and their motions, locations and local concentrations can be controlled. These forces can be exerted on both individual and clusters of particles. Having the capability to manipulate suspended particles gives users the ability for tuning the physical and, to some extent, the chemical properties of the suspension media, which addresses the needs of various advanced optofluidic systems. Additionally, the incorporation of particles results in the realization of novel optofluidic solutions used for creating optical components and sensing platforms. In this review, we present different types of active forces that are used for particle manipulations and the resulting optofluidic systems incorporating them. These systems include optical components, optofluidic detection and analysis platforms, plasmonics and Raman systems, thermal and energy related systems, and platforms specifically incorporating biological particles. We conclude the review with a discussion of future perspectives, which are expected to further advance this rapidly growing field.

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Six-stage cascade paramagnetic mode magnetophoretic separation system for human blood samples

Cited by 39 publications

References 46 publications

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Magnetophoretic-based microfluidic device for DNA isolation

Optofluidics incorporating actively controlled micro- and nano-particles

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